Acute and Sub-chronic Toxicity of Indole Alkaloids Extract from Leaves of Alstonia scholaris (L.) R. Br. in Beagle Dogs

Natural Products and Bioprospecting
Yun-Li ZhaoXiao-Dong Luo

Abstract

Alstonia scholaris (L.) R. Br., an evergreen tropical plant rich in indole alkaloids with significant physiological activity, is traditionally used to treat respiratory diseases in China. This study was conducted to establish the toxicity profile of the alkaloid extract (TA) of A. scholaris leaves in non-rodents. After oral administration of a single dose (4 g/kg.bw), a number of transient symptoms, such as unsteady gait, drooling, emesis, and reddening of peri-oral mucosa, were observed, but no treatment-related mortality. A sub-chronic toxicity study with a range of doses of TA (20, 60 and 120 mg/kg.bw) was conducted for a 13-week treatment period, followed by 4-week recovery observation. Except for emesis and drooling in majority of animals in 120 mg/kg.bw treatment group, no clinical changes were observed in TA-treated animals. Data from electrocardiography, bone marrow, urine, fecal, hematology and clinical chemistry analyses were comparable between TA-treated and control animals. No significant differences in the relative organ weights and histopathological characteristics were evident between the TA-treated and control groups. Accordingly, the non-observed-adverse-effect-level (NOAEL) of TA was established as 120 mg/kg.b...Continue Reading

References

Mar 30, 2007·Organic Letters·Xiang-Hai CaiXiao-Dong Luo
Jan 22, 2008·Organic Letters·Xiang-Hai CaiXiao-Dong Luo
Jul 18, 2009·Planta medica·Tao FengXiao-Dong Luo
Mar 12, 2010·Journal of Ethnopharmacology·Jian-Hua ShangXiao-Dong Luo
Apr 13, 2010·Journal of Ethnopharmacology·Jian-Hua ShangXiao-Dong Luo
Apr 5, 2012·ISRN Pharmacology·Seewaboon SireeratawongKanjana Jaijoy
Dec 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Vijayasteltar B LijuRamadasan Kuttan
Oct 30, 2014·Organic Letters·Xing-Wei YangXiao-Dong Luo
Aug 16, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jing CaoMin Ye
Aug 19, 2015·Natural Products and Bioprospecting·Xu-Jie QinXiao-Dong Luo
Dec 29, 2015·Journal of Ethnopharmacology·Yun-Li ZhaoXiao-Dong Luo
Jul 28, 2016·BMC Complementary and Alternative Medicine·Seewaboon SireeratawongKornkanok Ingkaninan
Mar 21, 2017·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yun-Li ZhaoXiao-Dong Luo
Jul 18, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jens BitzerKim A Henderson
Mar 3, 2018·Journal of Ethnopharmacology·Yun-Li ZhaoXiao-Dong Luo
Jun 20, 2018·Journal of Ethnopharmacology·Seong Eun JinHyekyung Ha
May 6, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rui LiRui Gao
Apr 3, 2020·Natural Products and Bioprospecting·Yun-Li ZhaoXiao-Dong Luo
May 11, 2020·Journal of Ethnopharmacology·Yun-Li ZhaoXiao-Dong Luo

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Citations

Jan 4, 2021·Natural Products and Bioprospecting·Yun-Li ZhaoXiao-Dong Luo
Nov 19, 2020·Drug Design, Development and Therapy·Abdrrahman Shemsu SururKaleab Asres
Jul 31, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Saikat MitraJesus Simal-Gandara

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