Acute and sub-chronic toxicity studies of Danshen injection in Sprague-Dawley rats

Journal of Ethnopharmacology
Meng WangJianming Cheng

Abstract

Salvia miltiorrhiza Bunge named Danshen in China has been used for hundreds of years in both China and other countries. Danshen injection made from the aqueous extract of Danshen which is widely adopted in China is one of the traditional Chinese medicine injections for preventing and treating cardiovascular diseases in most of the time. The present study was carried out on re-evaluating the safety of Danshen injection by determining toxicity after acute and sub-chronic administration in Sprague-Dawley (SD) rats. In acute toxicity study, rats (10 males and 10 females) were intravenously administered Danshen injection dose of 32g/kg body weight, two times in one day. General behavior, adverse effects and mortality were recorded for up to 14days post treatment. In the sub-chronic study, Danshen injection was given intravenously at the doses of 0, 1.92, 5.76, and 19.20g/kg per day (n=15/group each sex) for 13weeks to rats. Animal body weight and food intakes were observed weekly. Hematological, biochemical parameters and organ weight were determined in all animals at the end of the 13-week administration and 2-week recovery. However, histological examinations were carried out in the control and high-dose groups only. In acute study...Continue Reading

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Citations

Nov 29, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Ki Young ShinHyung Gun Lee
Aug 12, 2014·BioMed Research International·Tung-Ting ShamShun-Wan Chan
Jun 1, 2013·Journal of Toxicologic Pathology·Ying PiaoXiaodong Xie
Jul 6, 2019·Frontiers in Pharmacology·Lee Yen SimKhairana Husain
Mar 27, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Zhaojian ZhangXiumei Gao
Nov 8, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Jin-Seok LeeChang-Gue Son
Oct 1, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dimitrina Zheleva-DimitrovaNikolay Danchev
Nov 17, 2020·Drug Design, Development and Therapy·Rui GuoGuanwei Fan

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