Acute and sub-chronic toxicity study of diaveridine in Wistar rats

Regulatory Toxicology and Pharmacology : RTP
Xu WangZonghui Yuan

Abstract

Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. However, few studies have been performed to investigate its toxicity. To provide detailed toxicity with a wide spectrum of doses for diaveridine, acute and sub-chronic toxicity studies were conducted. Calculated LD50 was 2330 mg/kg b.w. in females and 3100 mg/kg b.w. in males, and chromodacryorrhea was noted in some females before their death. In the sub-chronic study, diaveridine was fed to Wistar rats during 90 days at dietary levels of 0, 23, 230, 1150 and 2000 mg/kg, which were about 0, 2.0-2.3, 21.0-23.5, 115.2-126.9 and 212.4-217.9 mg/kg b.w., respectively. Significant decrease in body weights in both genders at 1150 and 2000 mg/kg groups and significant increases in relative weights of brain in both genders, liver in females, kidneys and testis in males, alkaline phosphatase and potassium in both genders at 2000 mg/kg diet were noted. Significant decrease in absolute weights of several organs, hemoglobin and red blood cell count in both genders, albumin and total protein in females were observed at 2000 mg/kg diet. Fibroblasts in the kidneys, cell swelling of the glomerular zone in the adren...Continue Reading

References

May 1, 1968·British Journal of Pharmacology and Chemotherapy·S R Bushby, G H Hitchings
Sep 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W M LafranconiW L Wooding
Aug 15, 1993·Annals of Internal Medicine·H VelázquezD H Ellison
May 1, 1996·Kidney International·S Eiam-OngS Sabatini
Apr 15, 2003·Toxicology and Applied Pharmacology·Tsung-Ming ShihJohn H McDonough
Apr 8, 2010·Regulatory Toxicology and Pharmacology : RTP·Awais IhsanZong-hui Yuan
Aug 18, 2010·Regulatory Toxicology and Pharmacology : RTP·Xu WangZong-Hui Yuan
Jan 27, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xu WangZong-Hui Yuan
Sep 1, 1997·Environmental Toxicology and Pharmacology·T OnoT Ohta
Aug 19, 2011·Clinical Ophthalmology·Safak KarslıoğluMüslime Akbaba
Oct 28, 2011·The Veterinary Quarterly·H W Peek, W J M Landman
Jan 18, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xu WangZong-Hui Yuan
Jan 8, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Bruce H AckermanCynthia L Reigart
Jul 8, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hui WangXianhui Huang

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Citations

Sep 24, 2015·Environmental Toxicology and Pharmacology·Jianzhong WangXingyuan Cao
Jan 28, 2021·Journal of Chromatographic Science·Adel M MichaelChristine K Nessim

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