Acute and subacute stent thrombosis in a patient with clopidogrel resistance: a case report.

Korean Circulation Journal
Sung Soo KimJung Chaee Kang

Abstract

Drug-eluting stents (DES) are considered the treatment of choice for most patients with obstructive coronary artery disease when percutaneous intervention (PCI) is feasible. However, stent thrombosis seems to occur more frequently with DES and occasionally is associated with resistance to anti-platelet drugs. We have experienced a case of recurrent stent thrombosis in a patient with clopidogrel resistance. A 63-year-old female patient suffered from acute myocardial infarction and underwent successful PCI of the left anterior descending coronary artery (LAD) with two DESs. She was found to be hyporesponsive to clopidogrel and was treated with triple anti-platelet therapy (aspirin 100 mg, clopidogrel 75 mg, and cilostazol 200 mg daily). Three days after discharge, she developed chest pain and was again taken to the cardiac catheterization laboratory, where coronary angiography (CAG) showed total occlusion of the mid-LAD where the stent had been placed. After intravenous administration of a glycoprotein IIb/IIIa inhibitor, balloon angioplasty was performed, resulting in Thrombolysis In Myocardial Infarction (TIMI) III antegrade flow. The next day, however, she complained of severe chest pain, and the electrocardiogram showed marke...Continue Reading

References

Jul 27, 2001·The American Journal of Cardiology·P A GumE J Topol
Mar 8, 2008·Journal of the American College of Cardiology·José M de la Torre-HernándezUNKNOWN ESTROFA Study Group

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Citations

Mar 16, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yu MiaoJia De-An
Nov 21, 2013·Korean Circulation Journal·Hyun YangYun Kyung Park

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