Acute and subacute toxicity and chemical constituents of the hydroethanolic extract of Verbena litoralis Kunth

Journal of Ethnopharmacology
Rachel de LimaMelânia Palermo Manfron

Abstract

Verbena litoralis Kunth is a native species of South America, popularly known as gervãozinho-do-campo or erva-de-pai-caetano. It is used in gastrointestinal disorders, as detoxifying the organism, antifebrile properties and amidaglitis. To identify the chemical constituents of the hydroethanolic extract obtained from the aerial parts of V. litoralis and to evaluate the acute and sub-acute toxicity in male and female rats. The single dose (2000 mg/kg) of the extract was administered orally to male and female rats. In the subacute study the extract was given at doses of 100, 200 and 400 mg/kg during 28 days orally. Biochemical, hematological and histological analyzes were performed, oxidative stress markers were tested and chemical constituents were identified through UHPLC-ESI-HRMS RESULTS: Six classes of metabolites were identified: iridoids glycosides, flavonoids, phenylpropanoids-derived, phenylethanoid-derived, cinnamic acid-derived and triterpenes. In the acute treatment, the extract was classified as safe (category 5), according to the OECD guide. Our results demonstrated that subacute administration of the crude extract of V. litoralis at 400 mg/kg resulted in an increase in AST in males, whereas ALT enzyme showed a small...Continue Reading

Citations

Jun 16, 2019·Animals : an Open Access Journal From MDPI·Pavel HorkyJiri Skladanka
Aug 15, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Meilian YangGuiguang Cheng
Apr 28, 2019·Journal of Ethnopharmacology·Angelica VestenaGilsane von Poser

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