Acute and subchronic (28 days) oral toxicity studies of Codonopsis lanceolata extract in Sprague-Dawley rats

Regulatory Toxicology and Pharmacology : RTP
Jong Seok LeeOk-Hwan Lee

Abstract

Codonopsis lanceolata is a perennial plant that has been used as a food and in traditional medicine for the treatment of cough, bronchitis, and inflammation in East Asia including Korea, Japan, and China. However, information regarding its toxicity is limited. Therefore, we performed a safety evaluation of aqueous C. lanceolata root extract (CLE) in Sprague-Dawley rats. Assessment of acute toxicity revealed that CLE did not influence mortality, clinical appearance, body weight gain, or necropsy findings at a dose of 5000 mg/kg body weight. In the subchronic oral toxicity, data revealed that several significant alteration in food consumption, water consumption, protein excretion, WBCs levels, TGs, BUN levels, and the absolute and relative weights in the liver, spleen and lungs. However, these changes were transient and were not considered treatment related because they showed no apparent dose dependent. These results suggest that CLE (1250, 2500, and 5000 mg/kg body weight/day) administered orally does not cause acute or subchronic toxicity to male or female rats. The 50% lethal dose (LD50) of CLE was determined to be greater than 5000 mg/kg.

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Citations

Mar 2, 2016·Regulatory Toxicology and Pharmacology : RTP·MyoungLae ChoOk-Hwan Lee
Jul 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Sachinthi S AmarasiriLakmini K B Mudduwa
Nov 9, 2020·Natural Products and Bioprospecting·Christian Bailly
Feb 18, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Franz OeschThomas Efferth

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