Acute and subchronic nephrotoxicity of d-limonene in Fischer 344 rats.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
D R WebbC L Alden

Abstract

In the studies described here, we have examined the sex-specific sensitivity of rat kidney to d-limonene. At 24 hr after an acute dose of 200 mg d-limonene/kg body weight administered to adult male and female Fischer 344 rats by oral gavage, an increase in the incidence and severity of hyaline droplets was observed in the kidneys of males only. This histological change was accompanied by a treatment-related increase in alpha 2u-globulin in males only and a greater accumulation of radioactivity in renal cortex of the male rat compared with that in the females dosed with [14C]d-limonene. In a separate subchronic study, groups of 5-wk-old male rats were administered d-limonene in a corn oil vehicle at 0 (control), 2, 5, 10, 30, or 75 mg/kg body weight by single daily gavage (5 days/wk) for 13 wk. Rats from selected dose groups received interim necropsies from days 8-29, while all groups were necropsied at the end of the study. Linear regression analyses indicated a dose-related trend in the increased relative weights of the kidney and liver at 30 and 75 mg d-limonene/kg body weight. Histological examination of kidney tissue confirmed that d-limonene induced changes characterized by hyaline droplets, granular casts at the corticome...Continue Reading

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Citations

Oct 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D R WebbL D Lehman-McKeeman
Feb 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D JonkerV J Feron
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Nov 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D JonkerV J Feron
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Jun 14, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert L SmithUNKNOWN Expert Panel of the Flavor and Extract Manufacturers Association
Jul 10, 2012·Expert Opinion on Drug Metabolism & Toxicology·Andrea TrevisanPatrizia Cristofori
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