Acute and subchronic toxicity of inhaled toluene in male Long-Evans rats: Oxidative stress markers in brain

Neurotoxicology
Prasada Rao S KodavantiPhilip J Bushnell

Abstract

The effects of exposure to volatile organic compounds (VOCs), which are of concern to the EPA, are poorly understood, in part because of insufficient characterization of how human exposure duration impacts VOC effects. Two inhalation studies with multiple endpoints, one acute and one subchronic, were conducted to seek effects of the VOC, toluene, in rats and to compare the effects between acute and subchronic exposures. Adult male Long-Evans rats were exposed to toluene vapor (n=6 per group) at a concentration of 0 or 1019 ± 14 ppm for 6h in the acute study and at 0 ± 0, 10 ± 1.4, 97 ± 7, or 995 ± 43 ppm for 6h/d, 5d/week for 13 weeks in the subchronic study. For the acute study, brains were dissected on ice within 30 min of the end of exposure, while for the subchronic study, brains were dissected 18 h after the last exposure. Frontal cortex, hippocampus, cerebellum, and striatum were assayed for a variety of oxidative stress (OS) parameters including total aconitase (TA), protein carbonyls, glutathione peroxidase (GPX), glutathione reductase (GRD), glutathione transferase (GST), γ-glutamylcysteine synthetase (GCS), superoxide dismutase (SOD), total antioxidants (TAS), NADPH quinone oxidoreductase-1 (NQO1), and NADH ubiquinone...Continue Reading

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Citations

Aug 28, 2016·Environmental Science and Pollution Research International·Pardeep SinghPradeep Kumar Mishra
May 10, 2017·Journal of Cellular Biochemistry·Sara NiksereshtAbolhassan Ahmadiani
Sep 26, 2020·Frontiers in Neuroscience·Kevin M BraunscheidelJohn J Woodward
Oct 23, 2020·Chemical Reviews·Christopher P HopperBinghe Wang

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