PMID: 6540115Aug 1, 1984Paper

Acute anterior uveitis and hepatitis B virus infection

The British Journal of Ophthalmology
P I MurrayR S Tedder

Abstract

The aetiology of acute anterior uveitis (AAU) in the great majority of cases is unclear. Various infective agents have been postulated, however, as playing a direct or indirect part in the disease process, possibly via an immune-complex vasculitis. In an earlier study we concluded that, contrary to a previous report, hepatitis B virus (HBV) played only a small role, if any, in the pathogenesis of uveitis in Great Britain. Since we did not look for other markers of HBV infection other than hepatitis B surface antigen (HBsAg), it is possible that some cases of recent HBV infection may have been missed. In the present study 49 patients with AAU were tested for markers of hepatitis B infection. Sera from all patients tested were found to be negative for HBsAg and for antibody to the HBV core (anti-HBc), excluding HBV as a significant cause of AAU in this country. Since the quest for an infective agent in AAU may remain unproductive, future research on the aetiopathogenesis of AAU should include the study of tissue 'vulnerability' and the local and systemic immunoregulatory factors which modulate inflammatory responses.

References

Jan 1, 1979·International Archives of Allergy and Applied Immunology·B S AndrewsR Penny
May 1, 1979·American Journal of Ophthalmology·D H CharM Christensen
Jan 1, 1978·Annals of Internal Medicine·L M RyanR Eiferman
Apr 1, 1976·The British Journal of Ophthalmology·M S Norn
Jun 1, 1970·American Journal of Ophthalmology·R A Levine, P A Ward
Oct 4, 1980·Lancet·R B NussenblattI Gery
May 21, 1983·Lancet·P I MurrayW J Dinning
May 1, 1983·American Journal of Ophthalmology·R B NussenblattI Scher
Feb 1, 1983·Australian Journal of Ophthalmology·D WakefieldR Penny
Oct 1, 1983·The British Journal of Ophthalmology·P I MurrayA H Rahi
Feb 1, 1981·Clinical Immunology and Immunopathology·J T RosenbaumA Calin
May 1, 1981·The British Journal of Ophthalmology·J WelshA Ebringer

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Citations

Sep 28, 2010·La Revue de médecine interne·B Terrier, P Cacoub
Jun 2, 2009·Rheumatic Diseases Clinics of North America·Patrice Cacoub, Benjamin Terrier
Apr 6, 2002·Ocular Immunology and Inflammation·A KamalP I Murray

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