Acute antidepressant response and plasma levels of bupropion and metabolites in a pediatric-aged sample: an exploratory study.

Therapeutic Drug Monitoring
W Burleson DavissB Birmaher

Abstract

Studies examining associations between antidepressant response and plasma levels of bupropion and its metabolites have yielded contradictory findings. There have been no such studies in youth. This study explored such associations in 8 boys and 8 girls, age 11 to 17 years, all prescribed bupropion sustained release (SR) for major depression (n = 6) or depressive disorder not otherwise specified (n = 10) as part of a pharmacokinetic (PK) study. All were started on morning doses of bupropion SR of 100 mg/day, and most eventually had doses increased to 200 mg/day because of inadequate clinical response. After taking prescribed dose of bupropion SR at least 14 days (median = 21 days), subjects had steady-state serial plasma levels of bupropion and its metabolites measured during a 24-hour period after morning doses. A total of 9 subjects underwent these PK assessments on doses of 100 mg/day, and 6 underwent these on doses of 200 mg/day, with 4 studied on both doses. In this 24-hour assessment, the treating psychiatrist rated subjects' antidepressant response using the Clinical Global Impression's Improvement scale (CGI-I), blind to plasma levels, but informed by child and parent rating scales of depressive symptoms and clinical int...Continue Reading

References

Nov 15, 1977·Psychopharmacology·N ReisbyJ Christiansen
Nov 1, 1992·Biological Psychiatry·P J GoodnickN G Klimas
Mar 1, 1992·The American Journal of Psychiatry·P J Goodnick
Dec 1, 1991·Journal of Affective Disorders·E J CostelloD Silver
Oct 1, 1990·Journal of Clinical Psychopharmacology·C L DeVaneA A Lai
Feb 1, 1988·Archives of General Psychiatry·R N GoldenW Z Potter
Feb 1, 1995·Journal of Child Psychology and Psychiatry, and Allied Disciplines·A WoodR Harrington
May 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·L L BarrickmanE Schumacher
Oct 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·C K ConnersJ Ascher
Oct 27, 1998·Biological Psychiatry·P J GoodnickC L Bowden
Apr 6, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·W B DavissL Wiley
Nov 8, 2003·Journal of Child and Adolescent Psychiatric Nursing : Official Publication of the Association of Child and Adolescent Psychiatric Nurses, Inc·Carol A GlodRoss J Baldessarini
Mar 23, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·W Burleson DavissDavid A Brent

❮ Previous
Next ❯

Citations

Apr 28, 2012·Child and Adolescent Psychiatric Clinics of North America·Fadi T Maalouf, David A Brent
Jun 6, 2014·Journal of Medicinal Chemistry·Li-Fang YuAlan P Kozikowski
Nov 10, 2011·Pediatric Annals·Simona BujoreanuEva Szigethy
Sep 6, 2006·Child and Adolescent Psychiatric Clinics of North America·David A Brent, Boris Birmaher
Dec 1, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·W Burleson DavissDavid A Brent
Jun 4, 2016·The Journal of Pharmacology and Experimental Therapeutics·Andrea R MastersZeruesenay Desta
Apr 4, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Milan GrundmannRomana Urinovska
Aug 17, 2010·Expert Opinion on Pharmacotherapy·Fadi T Maalouf, David A Brent
May 19, 2020·Expert Opinion on Drug Safety·Sanne M KloosterboerBirgit C P Koch
May 13, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·C B EapC Hiemke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Academy of Child and Adolescent Psychiatry
W Burleson DavissL Wiley
Journal of Child and Adolescent Psychiatric Nursing : Official Publication of the Association of Child and Adolescent Psychiatric Nurses, Inc
Carol A GlodRoss J Baldessarini
Journal of the American Academy of Child and Adolescent Psychiatry
C K ConnersJ Ascher
Journal of the American Academy of Child and Adolescent Psychiatry
L L BarrickmanE Schumacher
© 2022 Meta ULC. All rights reserved