Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen

Agents and Actions
S Leyck, M Parnham

Abstract

Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a seleno-organic compound with glutathione peroxidase-like activity in vitro, was compared with indomethacin, BW 755C, and levamisole as an inhibitor of carrageenan- and CVF (cobra venom factor)-induced paw oedema in the rat. The antiinflammatory potency of ebselen against CVF-induced oedema (ED50 = 56 mg/kg p.o.) was similar to that of BW 755C, while indomethacin was weakly active in this model, and levamisole exerted stronger activity. In the carrageenan model, ebselen exhibited weak inhibitory potency, like BW 755C, while indomethacin markedly inhibited this inflammatory response, and levamisole was inactive. Unlike cyclooxygenase inhibitors, ebselen produced almost no gastric irritation in rats up to 316 mg/kg p.o. Moreover, ebselen inhibited significantly diclofenac-induced gastric intolerance at 31.6 and 316 mg/kg p.o. Thus, ebselen represents a new tool for antiinflammatory therapy.

References

Jun 1, 1988·Agents and Actions·R M McMillan, S J Foster
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S AbramsonG Weissmann
Feb 1, 1986·Prostaglandins·S T HoffsteinJ Gleason
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G A HiggsJ R Vane
Dec 1, 1987·Digestive Diseases and Sciences·G PihanS Szabo
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D K ImagawaM M Mayer
Jan 1, 1984·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·U AehringhausB M Peskar
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS

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Citations

Jan 1, 1991·Agents and Actions·M J ParnhamD R Blake
Nov 1, 1993·Agents and Actions·R A PatrickA C Issekutz
Jul 2, 2011·Archives of Toxicology·Cristina W Nogueira, João B T Rocha
Oct 1, 1995·General Pharmacology·T Schewe
Mar 1, 1993·Free Radical Biology & Medicine·H Sies
Sep 10, 2013·Biochemical Pharmacology·Michael J Parnham, Helmut Sies
Jul 14, 1997·Chemistry and Physics of Lipids·A BatnaG Spiteller
Sep 30, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Michael J Parnham
Oct 27, 2017·International Journal of Molecular Sciences·Bozena HosnedlovaRene Kizek
Apr 2, 2021·Archives of Toxicology·Cristina W NogueiraJoão B T Rocha
Dec 9, 2004·Chemical Reviews·Cristina W NogueiraJoão B T Rocha

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