Acute aseptic meningitis during isotretinoin treatment for nodular acne solely presenting with headache: case report and brief review of the literature

The International Journal of Neuroscience
Ioanna ChalimouAndreas A Argyriou

Abstract

Purpose/aim: We describe, in detail, the first case of isotretinoin-induced aseptic meningitis. A brief summary of the literature on drug-induced aseptic meningitis (DIAM) is also presented. A 20-year old female patient with probable (Naranjo adverse reaction probability score of 7) DIAM during treatment with isotretinoin therapy for nodular acne solely, presenting with headache. Pseudotumor cerebri was appropriately ruled-out. Summary of data altogether lead us suggest that isotretinoin triggered DIAM, possible due to a delayed hypersensitivity mechanism type III or IV. We highlight a quite uncommon cause of DIAM that may be increasing in frequency due to the current increasing use of isotretinoin against nodular acne.

References

Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Mar 30, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S JollesC Leighton
Mar 30, 2005·Expert Opinion on Drug Safety·Susan Hopkins, Stephen Jolles
Dec 17, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Elisabeth ChroniDionysios Tsambaos
Jun 19, 2013·Cephalalgia : an International Journal of Headache·UNKNOWN Headache Classification Committee of the International Headache Society (IHS)
Jul 9, 2014·JAMA Internal Medicine·German Morís, Juan Carlos Garcia-Monco
Jun 8, 2015·Current Pain and Headache Reports·Dagny Holle, Mark Obermann
May 11, 2018·Clinical Case Reports·Rogério Ruas, Natália Ribeiro

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