PMID: 9161656May 1, 1997Paper

Acute asthma associated with sustained-release verapamil

The Annals of Pharmacotherapy
L Ben-Noun

Abstract

To describe a patient with asymptomatic bronchial asthma and hypertension who developed an acute asthma attack after receiving sustained-release verapamil. A 66-year-old white woman with a 10-year history of hypertension and bronchial asthma was switched from immediate-release verapamil hydrocloride 40 mg tid to sustained-release verapamil 240 mg/d po for better hypertension control. After taking the first tablet, she developed dyspnea, cough, and wheezing. Antiasthmatic medications were prescribed, but the asthma symptoms did not improve. She continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil, and her asthma symptoms disappeared. On rechallenge she developed severe dyspnea, cough, and wheezing 20 minutes after administration. The asthma resolved within 24 hours following three albuterol inhalations. The next day similar symptoms developed with rechallenge of the same brand of sustained-release verapamil in a 120-mg formulation, and verapamil was discontinued. Six months later she was again prescribed sustained-release verapamil 240 mg in another clinic where the physician was unaware of her previous reaction. Once again, severe dyspnea, cough, and wheezi...Continue Reading

References

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Citations

Apr 24, 2008·Journal of Pharmacological Sciences·Seham MustafaAbdulhakeem Alsughayer
Nov 6, 2009·Current Gerontology and Geriatrics Research·Domenico Lorenzo Urso
Aug 17, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·L Ben-Noun

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