Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts.

Cardiovascular Research
Yanmin ZhangChristopher L-H Huang

Abstract

The experiments explored for atrial arrhythmogenesis and its possible physiological background in recently developed hetero-(RyR2(+/S)) and homozygotic (RyR2(S/S)) RyR2-P2328S murine models for catecholaminergic polymorphic ventricular tachycardia (VT) for the first time. They complement previous clinical and experimental reports describing increased ventricular arrhythmic tendencies associated with physical activity, stress, or catecholamine infusion, potentially leading to VT and ventricular fibrillation. Atrial arrhythmogenic properties were compared at the whole animal, Langendorff-perfused heart, and single, isolated atrial myocyte levels using electrophysiological and confocal fluorescence microscopy methods. This demonstrated that: (i) electrocardiographic parameters in intact anaesthetized wild-type (WT), RyR2(+/S) and RyR2(S/S) mice were statistically indistinguishable both before and after addition of isoproterenol apart from increases in heart rates. (ii) Bipolar electrogram and monophasic action potential recordings showed significantly higher incidences of arrhythmogenesis in isolated perfused RyR2(S/S), but not RyR2(+/S), relative to WT hearts during either regular pacing or programmed electrical stimulation. The ...Continue Reading

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Citations

Apr 11, 2012·Clinical and Experimental Pharmacology & Physiology·Laila GuzadhurChristopher L-H Huang
Dec 26, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jere PaavolaMatti Viitasalo
Mar 23, 2011·Pharmacology & Therapeutics·Jérôme ThireauSylvain Richard
Jul 15, 2015·Scientific Reports·Wenjun XieAndrew R Marks
Nov 8, 2015·Pflügers Archiv : European journal of physiology·Feifei NingSamantha C Salvage
Apr 11, 2015·Frontiers in Physiology·Yue-Kun JuMark B Cannell
Feb 8, 2011·Cardiovascular Research·Dobromir Dobrev, Stanley Nattel
Dec 2, 2015·Biochimica Et Biophysica Acta·Sören BrandenburgStephan E Lehnart
Dec 16, 2016·Physiological Reviews·Christopher L-H Huang
Aug 20, 2017·Pflügers Archiv : European journal of physiology·Shiraz AhmadChristopher L-H Huang
Sep 30, 2017·Experimental Physiology·Haseeb ValliChristopher L-H Huang
Apr 28, 2019·Journal of Cell Science·Samantha C SalvageAngela F Dulhunty
Nov 8, 2012·Journal of Cardiovascular Electrophysiology·Yanmin ZhangJames A Fraser
Feb 8, 2019·Cardiovascular & Hematological Disorders Drug Targets·Estefanía Lozano-VelascoDiego Franco
Aug 14, 2020·International Journal of Molecular Sciences·Estefanía Lozano-VelascoHouria Daimi
Sep 28, 2017·Clinical and Experimental Pharmacology & Physiology·Shiraz AhmadChristopher L-H Huang
Oct 14, 2021·Biochemical Society Transactions·Samantha C SalvageChristopher L-H Huang

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Methods Mentioned

BETA
genetic modifications
fluorescence microscopy
confocal microscopy

Software Mentioned

SPSS
Spike2
Chart

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