Acute attenuation of glycocalyx barrier properties increases coronary blood volume independently of coronary flow reserve

American Journal of Physiology. Heart and Circulatory Physiology
Judith BrandsJurgen W G E VanTeeffelen

Abstract

Vascular endothelium is covered with an extensive mesh of glycocalyx constituents, which acts like an effective barrier up to several micrometers thick that shields the luminal surface of the vasculature from direct exposure to flowing blood. Many studies report that various enzymatic and pharmaceutical challenges are able to increase glycocalyx porosity, resulting in farther permeation of plasma macromolecules and greater access of red blood cells into glycocalyx domain. Attenuation of glycocalyx barrier properties therefore potentially increases the amount of blood that effectively occupies available microvascular volume. We tested in the present study whether attenuation of coronary glycocalyx barrier properties actually increases coronary blood volume and whether such changes would be noticeable during measurements of coronary flow reserve using adenosine. In anesthetized goats (n = 6) with cannulated left main coronary artery that were perfused under controlled pressure, coronary blood volume was measured via the indicator-dilution technique using high-molecular-weight (2,000 kDa) dextrans as plasma tracer and labeled red blood cells as red blood cell tracer. Coronary blood volume was determined at baseline and during intr...Continue Reading

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Citations

Dec 5, 2013·Physiological Reports·Judith BrandsJurgen W G E Vanteeffelen
Nov 19, 2011·Medical & Biological Engineering & Computing·Judith BrandsJurgen W G E Van Teeffelen
Sep 23, 2010·Basic Research in Cardiology·Bernhard F BeckerMatthias Jacob
Aug 1, 2012·Scandinavian Cardiovascular Journal : SCJ·Ari Adolf MennanderMatti Tarkka
Jan 24, 2012·Journal of Molecular and Cellular Cardiology·Dursun GündüzThomas Noll
Oct 10, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Minako Yamaoka-Tojo
Jul 14, 2012·JACC. Cardiovascular Imaging·Soo-Jin KangSeung-Jung Park
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Evan D McConnellMaiken Nedergaard
May 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·P Mason McClatcheyJane E B Reusch

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