Acute Basilar Artery Occlusion: Does Recanalization Improve Clinical Outcome? A Critically Appraised Topic

The Neurologist
Chia-Chun ChiangCumara B O'Carroll

Abstract

Acute basilar artery occlusion (BAO) is a devastating, life-threatening condition that accounts for approximately 1% of all strokes. Currently, there is no consensus on the best treatment strategy for patients with BAO. Whereas endovascular reperfusion therapy is proven to improve outcomes in anterior circulation stroke, its benefit in acute BAO has not been confirmed in randomized controlled trials. To critically assess the current evidence regarding recanalization in acute BAO, and to discuss the outcomes of different treatment strategies in the management of acute BAO. The objective was addressed through the development of a critically appraised topic that included a clinical scenario, structured question, literature search strategy, critical appraisal, assessment of results, evidence summary, commentary, and bottom-line conclusions. Participants included consultant and resident neurologists, and content experts in the field of vascular and hospital neurology. A recent meta-analysis was selected for critical appraisal to assess the recanalization hypothesis in acute BAO. The authors performed a systematic literature search through August 2013 and pooled in the analysis of 45 studies and 2056 patients. The overall recanalizat...Continue Reading

References

Jan 28, 2006·Stroke; a Journal of Cerebral Circulation·Perttu J Lindsberg, Heinrich P Mattle
Oct 22, 2011·Lancet Neurology·Heinrich P MattleGerhard Schroth
Mar 29, 2013·Annals of Neurology·Daniel StrbianPerttu J Lindsberg
Oct 2, 2014·Journal of Neurointerventional Surgery·Gyanendra KumarAndrei V Alexandrov
Dec 24, 2015·Stroke; a Journal of Cerebral Circulation·Bart M DemaerschalkUNKNOWN American Heart Association Stroke Council and Council on Epidemiology and Prevention

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