Acute bilateral simultaneous angle closure glaucoma after topiramate administration: a case report

Journal of Medical Case Reports
Kakarla V ChalamVikram S Brar

Abstract

A case of severe acute bilateral angle closure glaucoma with complete visual loss after oral topiramate therapy. A 34 year-old woman developed bilateral severe visual loss 2 days after doubling the dosage of topiramate. Her best-corrected visual acuity (BCVA) was counting fingers in both eyes (OU). Intraocular pressures were 49 mm and 51 mm of Hg in right and left eyes respectively, with conjunctival chemosis, corneal edema, shallow anterior chamber and closed angles on gonioscopy. B-scan ultrasound revealed annular peripheral choroidal effusions in both eyes. Intraocular pressures and anterior chamber depth were normalized after discontinuation of topiramate and initiation of antiglaucoma therapy. Two weeks later, visual acuities improved to 20/25 in the right eye and 20/40 in the left eye. B-scan ultrasound showed resolution of choroidal effusion. Topiramate, an oral sulpha-derivative medication is known to cause ciliochoroidal effusions, which lead to forward rotation of the ciliary body and displacement of the lens-iris diaphragm, with resultant acute angle closure glaucoma and myopic shift.

References

Jul 5, 2001·American Journal of Ophthalmology·J T BantaD S Greenfield
Feb 14, 2003·Archives of Ophthalmology·Felipe A MedeirosRobert N Weinreb
Jan 1, 2004·American Journal of Ophthalmology·Jamie E CraigJane M Wells
Jan 9, 2004·Ophthalmology·F W FraunfelderEdwin U Keates
Sep 15, 2004·Neurology·P RaskinUNKNOWN CAPSS-141 Study Group
Jul 27, 2005·Archives of Internal Medicine·Bankole A JohnsonMartin A Javors
Jun 13, 2006·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Jaime LevyTova Lifshitz
Feb 16, 2007·Headache·Stephen D SilbersteinUNKNOWN Topiramate Chronic Migraine Study Group
Jun 6, 2007·Drugs·Elon EisenbergNorberto Krivoy
Oct 10, 2007·Acta Neurologica Scandinavica·N CelebisoyO Akyürekli
Oct 11, 2007·JAMA : the Journal of the American Medical Association·Bankole A JohnsonUNKNOWN Topiramate for Alcoholism Study Group

❮ Previous
Next ❯

Citations

Feb 18, 2011·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A ZimmermannW Schmidt
Dec 14, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Cagatay CaglarDogan Ceyhan
Jan 26, 2012·Clinical Ophthalmology·Mohammad-Ali AbtahiMojtaba Akbari
Oct 16, 2009·Cases Journal·Sandra D Gawley
Jul 21, 2011·Indian Journal of Psychiatry·Keshava Pai, Pooja Rajashekaran
Jan 1, 2011·Digital Journal of Ophthalmology : DJO·Pedro BarrosPaula Tenedorio
Jan 1, 2014·Journal of Medical Case Reports·Nobuhiro HaradaNorihiro Kokudo
Feb 5, 2014·Anesthesiology Clinics·Mary C Theroux, Sabina DiCindio
Jan 30, 2013·The Journal of Emergency Medicine·Matthew BivensAshleigh Hegedus
Sep 24, 2011·Medicina clínica·María Jesús Muniesa RoyoCarmen Jurjo Campo
Dec 17, 2009·The Journal of Emergency Medicine·Kendra L ColeRichard M Aronwald
Oct 1, 2009·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Essam A OsmanSaleh A Al Obeidan
Jun 1, 2017·Medicine·Cherng-Ru HsuDa-Wen Lu
Dec 15, 2015·Eye & Contact Lens·Patricia Chirinos-SaldañaEnrique O Graue-Hernández
Apr 15, 2009·Journal of Glaucoma·Zaher SbeityRobert Ritch
Feb 11, 2020·American Journal of Therapeutics·Vikrant TambeMatthew Hess
Jan 1, 2019·Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti·L HlavatáP Lišková
Jan 1, 2019·Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti·J ŠtěpánkováD Dotřelová
Jan 1, 2012·Journal of Current Glaucoma Practice·Aruj K KhuranaAshok K Khurana
Jul 3, 2021·Journal of Clinical Medicine·Adela Magdalena CiobanuOvidiu Popa-Velea

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved