Acute blockade of nitric oxide synthase inhibits renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats

The Journal of Clinical Investigation
Lee A Danielson, Kirk P Conrad

Abstract

Because the kidneys are vasodilated and the endogenous production of nitric oxide is increased in gravid rats, we tested whether nitric oxide mediates the renal vasodilatory response to pregnancy. Chronically instrumented, conscious rats of gestational days 12-14 were studied concurrently with age-matched virgin control animals. GFR and effective renal plasma flow (ERPF) were determined by the renal clearances of inulin and para-aminohippurate before and during acute infusion of N omega-nitro-L-arginine methyl ester (NAME; 2, 20, and 50 micrograms/min) or NG-monomethyl-L-arginine (100 micrograms/min). Baseline GFR and ERPF were significantly increased, and effective renal vascular resistance was decreased by 30-40% in gravid rats compared with virgin controls. During infusion of all three dosages of NAME and NG-monomethyl-L-arginine, effective renal vascular resistance, GFR, and ERPF were equalized in the pregnant and virgin rats (the only exception being GFR during the 20 micrograms/min NAME infusion). When compared with virgin rats, the gravid animals were more responsive to nitric oxide synthase inhibition, showing a significantly greater decline in GFR and ERPF and rise in effective renal vascular resistance at each timepoi...Continue Reading

References

Jun 1, 1992·Hypertension·J D Imig, R J Roman
May 1, 1990·Hypertension·S M GardinerS Moncada
Apr 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K P Conrad
Apr 1, 1967·The Journal of Clinical Endocrinology and Metabolism·L C Chesley, I H Tepper
Jul 22, 1993·Annals of the New York Academy of Sciences·K P ConradH Valtin
Sep 1, 1963·Circulation Research·L C CHESLEYN I SILVERMAN

❮ Previous
Next ❯

Citations

Apr 25, 2012·Cell and Tissue Research·Linda A GalloMary E Wlodek
Dec 23, 2008·Heart Failure Reviews·Sam L TeichmanGad Cotter
Oct 6, 2011·Current Hypertension Reports·Kirk P Conrad, Sanjeev G Shroff
Mar 5, 2003·Advances in Renal Replacement Therapy·Chris Baylis
Sep 7, 2000·Obstetrical & Gynecological Survey·L CarbillonS Uzan
Oct 12, 2010·Cardiology in Review·Jason Grossman, William H Frishman
Jun 1, 1996·British Journal of Pharmacology·G LosonczyR Venuto
May 27, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kirk P Conrad
Nov 27, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Virginia L BrooksRobert K Goldman
Jul 30, 2010·American Journal of Physiology. Renal Physiology·Jennifer M SasserChris Baylis
Jul 16, 2010·American Journal of Physiology. Renal Physiology·Cheryl A SmithChris Baylis
Sep 28, 2006·American Journal of Physiology. Renal Physiology·Sarah KnightChris Baylis
Apr 24, 2012·Journal of Pregnancy·N VitoratosC Iavazzo
Jul 1, 1995·The Journal of Clinical Investigation·J G Umans, M Lindheimer
Jun 8, 2001·The Journal of Clinical Investigation·J NovakK P Conrad
Feb 18, 1999·The Journal of Clinical Investigation·L A DanielsonK P Conrad
May 31, 2013·The Journal of Endocrinology·Jordan M WillcoxCoral L Murrant
Jul 1, 1995·Kidney International·L Raij, C Baylis
Nov 13, 2012·Drug Discovery Today. Disease Models·Jt McGuane, Kp Conrad
Jan 27, 2011·Seminars in Nephrology·Tom CornelisMichelle Hladunewich
Dec 6, 2006·The Urologic Clinics of North America·Arundhathi Jeyabalan, Kristine Y Lain
Jun 16, 2005·Annals of the New York Academy of Sciences·Kirk P ConradJacqueline Novak
May 7, 2009·Annals of the New York Academy of Sciences·Jonathan T McGuaneKirk P Conrad
May 3, 2011·American Journal of Obstetrics and Gynecology·Joris van DrongelenMarc E A Spaanderman
Jan 10, 1998·American Journal of Obstetrics and Gynecology·T Hines, S W Mifflin
Sep 27, 2014·Immunobiology·Vânia BrazãoAna Amélia Carraro-Abrahão
Sep 1, 1996·American Journal of Obstetrics and Gynecology·M YamasakiJ G Umans
Oct 2, 2004·Journal of the Society for Gynecologic Investigation·Kirk P Conrad
Jun 29, 2004·Journal of the Society for Gynecologic Investigation·Jacqueline NovakKirk P Conrad
Dec 5, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Lucimeire N CarvalhoMirian A Boim
Jul 24, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kirk P Conrad, Jacqueline Novak
Jun 30, 2018·Current Opinion in Nephrology and Hypertension·Aline M A de Souza, Crystal A West
May 26, 2010·Hypertension·Kirk P Conrad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Clinical Investigation
Lee A DanielsonKirk P Conrad
Journal of the Society for Gynecologic Investigation
Jacqueline NovakKirk P Conrad
Journal of the American Society of Nephrology : JASN
Marie C SmithJohn M Davison
© 2021 Meta ULC. All rights reserved