Acute blood glucose lowering effects and long-term safety of OpunDia supplementation in pre-diabetic males and females

Journal of Ethnopharmacology
Michael P GodardBjörn Feistel

Abstract

The aim of this study was to evaluate the acute and chronic effects of OpunDia (Opuntia ficus-indica) in obese pre-diabetic men and women. This double-blind placebo controlled study included participants (age range of 20-50 years) randomly assigned to one of the two groups and given a 16-week supply of either the 200 mg OpunDia (n=15), or placebo (n=14). The acute phase of the study consisted of an oral glucose tolerance test (OGTT) with a 400 mg bolus of OpunDia given 30 min before orally ingesting a 75 g glucose drink. Baseline and post 16-week concentrations of glucose, insulin, hsCRP, adiponectin, proinsulin, Hb1Ac, cholesterol, and a comprehensive metabolic panel were collected along with body composition measured via densitometry (BOD POD). A repeated measures ANOVA was conducted to determine any significant interactions between group and time. Follow-up analysis was performed to determine differences among groups at each time point. Paired t-tests were performed on all variables to determine if any within group differences existed across time. There was a statistically significant decrease (P<0.05) in the blood glucose concentrations at the 60 (205.92+/-36.90 and 188.84+/-38.43 mg/dL, respectively), 90 (184.55+/-33.67 an...Continue Reading

References

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Citations

Oct 23, 2013·Journal of the International Society of Sports Nutrition·Louise DeldicquePeter Hespel
Jun 20, 2013·Journal of Diabetes and Metabolic Disorders·Shirin Hasani-RanjbarMohammad Abdollahi
Sep 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karym El-MostafaMustapha Cherkaoui-Malki
Sep 26, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Pee-Win ChongRalf Uebelhack
Nov 30, 2010·Journal of Ethnopharmacology·Adolfo Andrade-Cetto, Helmut Wiedenfeld
Dec 14, 2011·Journal of Ethnopharmacology·Jaime Becerra-Jiménez, Adolfo Andrade-Cetto
May 8, 2016·Journal of Ethnopharmacology·Ashutosh SharmaMaría Luisa Villarreal
May 31, 2018·Critical Reviews in Food Science and Nutrition·Parisa RahimiAlireza Ostadrahimi
Oct 13, 2019·Current Pharmaceutical Design·Paola Isabel Angulo-BejaranoOctavio Paredes-López
Mar 2, 2018·Therapeutic Advances in Endocrinology and Metabolism·Sudhanshu Kumar BhartiAwanish Kumar
May 12, 2017·Oxidative Medicine and Cellular Longevity·María Del Socorro Santos DíazAnne Nègre-Salvayre
Oct 8, 2020·Phytotherapy Research : PTR·Gitishree DasJayanta Kumar Patra
Nov 12, 2020·International Journal of Molecular Sciences·Andrea Gómez-MaqueoJorge Welti-Chanes

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