PMID: 9171960Jun 1, 1997Paper

Acute but not chronic angiotensin-converting enzyme inhibition induces enzyme synthesis in the glomerulus of the spontaneously hypertensive rat

Clinical and Experimental Pharmacology & Physiology
G HodgeK A Duggan

Abstract

1. Treatment with angiotensin-converting enzyme (ACE) inhibitors slows the rate of progression of nephropathy in the spontaneously hypertensive rat (SHR) with streptozotocin-induced diabetes. Paradoxically, however, chronic ACE inhibitor therapy has been reported to be associated with induction of ACE in the plasma. We sought to determine whether induction also occurred in the glomerulus. 2. Seven days after induction of diabetes rats were randomized to receive perindopril (4 mg/kg per day) in the drinking water or water alone. Blood glucoses were maintained 6-10 mmol/L by daily ultralente insulin. Rats were killed after 1 and 12 weeks of ACE inhibitor therapy and the kidneys were harvested. Angiotensin-converting enzyme activity was determined in isolated glomeruli before and after removal of perindopril and reconstitution with zinc sulphate. 3. After 1 week of ACE inhibitor therapy, glomerular ACE was significantly greater after removal of perindopril than either before its removal (P < 0.025) or in the untreated controls (P < 0.025). After 12 weeks of therapy, ACE activity was significantly lower in the perindopril-treated group than in the untreated controls (P < 0.025). There was no increase in ACE activity following remov...Continue Reading

References

May 1, 1992·Clinical and Experimental Pharmacology & Physiology·K JandeleitM E Cooper
Jan 1, 1992·Clinical and Experimental Pharmacology & Physiology. Supplement·S Y ChaiC I Johnston
Feb 8, 1992·BMJ : British Medical Journal·S BjörckM Aurell
Apr 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·Y TokitaP J Mulrow
Jul 1, 1994·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·A BenetosM E Safar
Aug 1, 1993·The American Journal of Physiology·B S McAllisterM S Olson

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Citations

Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gert Mayer

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