Acute caffeine effects on urine composition and calcium kidney stone risk in calcium stone formers

The Journal of Urology
Linda K Massey, Roger A L Sutton

Abstract

Caffeine increases urinary calcium (ca) excretion in nonstone formers. We designed a study to determine the effect of caffeine consumption on urinary composition in stone formers. A total of 39 normocalcemic patients with calcium stones consumed caffeine (6 mg/kg lean body mass) after 14 hours of fasting. Urinary composition was compared 2 hours before and 2 hours after caffeine consumption. Control subjects included 9 nonstone formers studied contemporaneously with patients plus data from 39 nonstone formers from previous studies matched to each patient by level of fasting calcium/creatinine (Cr), gender and age. Caffeine increased urinary Ca/Cr, magnesium/Cr, citrate/Cr and sodium/Cr but not oxalate/Cr in stone formers and controls. The Tiselius stone risk index for calcium oxalate precipitation increased from 2.4 to 3.1 in stone formers and from 1.7 to 2.5 in nonstone formers. Of the 39 stone formers 32 had an increased Tiselius risk index after caffeine. Post-caffeine increases in Ca/Cr and Na/Cr were highly correlated. Caffeine consumption may modestly increase risk of calcium oxalate stone formation.

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Citations

Jan 13, 2006·Urological Research·Roswitha Siener
Jul 16, 2010·Urological Research·Elaine M Worcester, Fredric L Coe
Nov 12, 2005·World Journal of Urology·Roswitha Siener, Albrecht Hesse
Mar 12, 2009·Journal of Endourology·Corey M PassmanDean G Assimos
Nov 10, 2013·BMC Nephrology·Tobias SchoenUNKNOWN Swiss Survey on Salt investigators
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Jun 26, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Davide BolignanoMichele Buemi
Apr 22, 2015·The Journal of Urology·Dean G Assimos
Jan 15, 2014·The Journal of Urology·Dean G Assimos
Sep 10, 2010·Current Sports Medicine Reports·E Randy Eichner
Jul 23, 2018·Advances in Nutrition·Paleerath Peerapen, Visith Thongboonkerd
Jul 1, 2005·The Journal of Nutrition·Linda K MasseySusan A Kynast-Gales
Jan 19, 2021·World Journal of Urology·Yazeed BarghouthyOlivier Traxer
Jan 4, 2021·Journal of Environmental Management·S KeerthananMeththika Vithanage
Oct 15, 2020·World Journal of Urology·Yazeed BarghouthyOlivier Traxer
Nov 5, 2021·Plant Foods for Human Nutrition·Fahimeh HaghighatdoostBehnood Abbasi

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