Acute Cardiac Injury in COVID-19: A Systematic Review and Meta-analysis

Archives of Iranian Medicine
Mehrbod VakhshooriNizal Sarrafzadegan

Abstract

Coronavirus disease 2019 (COVID-19) has been widespread since late December 2019, with several symptoms related to the upper and lower respiratory system. However, its cardiac manifestations are less frequently studied. We aimed to analyze the available COVID-19 data on acute cardiac injury, using troponin and brain natriuretic peptide (BNP) levels. We performed a systematic review on Medline/PubMed, Scopus, and Google Scholar databases until March 25, 2020. Relevant records reporting the incidence of acute cardiac injury as well as troponin and BNP levels were collected from published peer-reviewed articles with further analysis according to the clinical status of the patients (severe, non-severe, and death). Eleven records of 1394 individuals were included. The mean age of patients with acute cardiac injury was 56.6 ± 33.4 years (males: 54.3%). The incidence of acute cardiac injury was 15% (95% CI: 11, 20%). Further analysis revealed that dead or severe patients had significantly higher percentages of myocardial injury, compared to non-severe ones (peer-reviewed: 44%, 95% CI: 16, 74% vs. 24%, 95% CI: 15, 34% vs. 5%, 95% CI: 1, 12%, respectively). Mean total troponin was 10.23 pg/mL (95% CI: 5.98, 14.47), while 13% (95% CI: 8%...Continue Reading

Citations

Mar 10, 2021·International Journal of Health Services : Planning, Administration, Evaluation·Seyed A NejadghaderiNima Rezaei
Mar 16, 2021·Emergent Materials·Amene Saghazadeh, Nima Rezaei
Apr 3, 2021·Archives of Gynecology and Obstetrics·Mona MirbeykNima Rezaei
Apr 16, 2021·Frontiers in Cardiovascular Medicine·Saeideh Aghayari Sheikh NeshinRamin Zand
May 3, 2021·Journal of Neuroimmunology·Homa PourriyahiNima Rezaei
May 6, 2021·Journal of Cardiovascular Pharmacology and Therapeutics·Antonis S ManolisHelen Melita

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