PMID: 6986186Feb 24, 1980Paper

Acute central stimulation of luteinizing hormone by parenterally administered N-methyl-D,L-aspartic acid in the male rat

Brain Research
B A Schainker, T J Cicero

Abstract

N-methyl-D,L-aspartic acid (NMA), a potent neuroexcitatory and neurotoxic glutamic acid analogue, acutely elevated serum luteinizing hormone (LH) in male rats when given subcutaneously in doses below those that cause morphologically detectable hypothalamic neurotoxicity. NMA treatment in doses known to be subtoxic by morphological criteria fails to induce any permanent neuroendocrine dysfunction as assessed by several physiological parameters, including NMA responsiveness after multiple consecutive dosees spaced at 24 h intervals, subsequent basal LH levels and subsequent postcastration LH elevations. Like naloxone, NMA elevates serum LH by reversibly stimulating a central labile pool. Neither has a direct stimulatory effect on the pituitary in vitro. Treatment with either attenuates naloxone-induced LH stimulation 2 h, but not 14 days, later while pituitary responsiveness to LHRH in vivo remains unaltered. Neither NMA nor naloxone is dependent upon testosterone for its LH stimulatory action and both increase serum LH through physiological mechanisms responsive to testosterone inhibition. It is concluded that subtoxic LH stimulating doses of NMA provide a useful tool in discerning neurotransmitter systems involved in central co...Continue Reading

References

Feb 1, 1976·Endocrinology·J S KizerM J Brownstein
Aug 1, 1971·Experimental and Molecular Pathology·A Van Harreveld, E Fifkova
May 1, 1969·Endocrinology·G D NiswenderA V Nalbandov

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Citations

Feb 1, 1994·Amino Acids·M ZanisiM Galbiati
Feb 27, 2007·Reviews in Endocrine & Metabolic Disorders·Waljit S DhilloStephen R Bloom
Jan 1, 1988·Physiology & Behavior·E H Schlenker, M Goldman
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·K MaedaA Yokoyama
Jan 1, 1990·Brain Research. Brain Research Reviews·J W McDonald, M V Johnston
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M Zanisi, E Messi
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·L J Filer, L D Stegink
Dec 19, 1983·Brain Research·G A MasonC B Nemeroff
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A D'AnielloD Ingrosso
Apr 1, 1995·The American Journal of Physiology·D R GrattanM Selmanoff

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