Acute Chagas' disease: plasma levels of alpha-2-macroglobulin and C-reactive protein in children under 13 years in a high endemic area of Bolivia

Journal of Tropical Pediatrics
N MedranoT C Araújo-Jorge

Abstract

We measured the levels of two human acute phase proteins (APP), alpha-2-macroglobulin (A2M) and C-reactive protein (CRP), in sera of 56 healthy and 84 acute chagasic children aged from 1 to 13 years old, from a highly endemic area in Bolivia. In such areas, children are continuously exposed to vectors and the frequency of acute cases increases with age. Quantitation of A2M and CRP were performed using sandwich ELISAs, that were shown to be sensitive, reproducible and suited for studying many samples rapidly. A2M levels observed were higher in healthy younger children, decreasing with age until children reached their teens, and their distribution suggested a relationship between A2M concentration and age that could be consistently expressed by a power function. The same does not occur with CRP levels. Concentrations of A2M were age-adjusted to allow comparison using sera collected from children with different ages. Both A2M and CRP were significantly increased in acute chagasic children. Since parasites are commonly present in blood and tissues during the acute phase of Chagas' disease, it is possible that the high levels of A2M may act as inhibitors of a high load of proteinases, derived either from the parasites, from host cel...Continue Reading

Citations

Apr 20, 2010·Micron : the International Research and Review Journal for Microscopy·M M PaivaT C Araújo-Jorge
Jan 26, 2006·Revista española de cardiología·Lyankis LópezRafael Bonfante-Cabarcas
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Constança Carvalho Britto
May 7, 2002·Memórias do Instituto Oswaldo Cruz·José Rodriques Coura, Solange L de Castro
Mar 16, 2005·Revista Da Sociedade Brasileira De Medicina Tropical·Adriano Gomes SilvaSilvio Favoreto Junior
Nov 26, 2003·Scandinavian Journal of Immunology·R Sathler-AvelarO A Martins-Filho
Nov 21, 2018·Canadian Journal of Physiology and Pharmacology·Ryan CookCarlos Fernandez-Patron
May 3, 2002·Journal of Medicinal Chemistry·Cleverson Neves-PintoAntônio Ventura Pinto
Oct 10, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Annekathrin HaberlandIngolf Schimke

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