Acute changes in nerve excitability following oxaliplatin treatment in mice.

Journal of Neurophysiology
Preet G S MakkerGila Moalem-Taylor

Abstract

Oxaliplatin chemotherapy produces acute changes in peripheral nerve excitability in humans by modulating voltage-gated Na+ channel activity. However, there are few animal studies of oxaliplatin-induced neuropathy that demonstrate similar changes in excitability. In the present study, we measured the excitability of motor and sensory caudal nerve in C57BL/6 mice after oxaliplatin injections either systemically (intraperitoneal) or locally (intramuscular at the base of the tail). As opposed to intraperitoneal administration of oxaliplatin, a single intramuscular injection of oxaliplatin produced changes in both motor and sensory axons. In motor axons, oxaliplatin caused a greater change in response to long-lasting depolarization and an upward shift in the recovery cycle, particularly at 24 h [depolarizing threshold electrotonus (TEd) 10-20 ms, P = 0.0095; TEd 90-100 ms, P = 0.0056) and 48 h (TEd 10-20 ms, P = 0.02; TEd 90-100 ms, P = 0.04) posttreatment. Oxaliplatin treatment also stimulated the production of afterdischarges in motor axons. These changes were transient and showed dose dependence. Mathematical modeling demonstrated that these changes could be accounted for by slowing inactivation of voltage-gated Na+ channels by 7...Continue Reading

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Citations

Jan 13, 2021·Journal of the Peripheral Nervous System : JPNS·Preet G S MakkerGila Moalem-Taylor
Apr 30, 2021·Frontiers in Immunology·Daniel B LowyGila Moalem-Taylor
Jun 19, 2021·The Ocular Surface·Jeremy Chung Bo ChiangMaria Markoulli
Oct 17, 2021·Oncology and Therapy·Jamie BurgessUazman Alam

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