Acute changes in osmolality and renin and respiratory control of arterial PCO2 and [H+

Respiration Physiology
J W AndersonD B Jennings

Abstract

To investigate whether osmoreceptor mechanisms or the renin-angiotensin system might be involved in respiratory regulation of H+ homeostasis, plasma osmolality was acutely lowered by approximately 10 mOsm in 7 awake mongrel dogs by a gastric water load (20 ml.kg-1 distilled, deionized water). Plasma renin activity (PRA) was measured as an indicator of angiotensin II levels. During these studies PaCO2 and [H+]a reflected the spontaneous level of ventilation (VE); higher levels of VE were correlated with lower PaCO2 and [H+]a, indicating a nonchemical drive to breathe. Stimulation of ventilation to lower PaCO2 following the water load was positively correlated with increase in PRA and decrease in plasma osmolality, but not with change in osmolality alone. An increased VE, a decreased ventilatory response curve (VRC) threshold for PaCO2, and a lower PaCO2 occurred with increase in PRA. Conversely, a lower or acutely decreased PRA, due to administration of arginine vasopressin, was correlated with a lower VE, an increase in the VRC threshold for PaCO2, and a higher PaCO2. Ventilatory control of PaCO2 during acute lowering of osmolality may be related to a central inter-action between osmolality and the renin-angiotensin system.

References

Apr 1, 1979·Respiration Physiology·E K Potter, D I McCloskey
May 15, 1979·Pflügers Archiv : European journal of physiology·R Gallego, C Belmonte
Feb 1, 1989·Clinical Biochemistry·I R SardaA J de Bold
Jul 1, 1985·Brain Research Bulletin·P M Gross
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·A MorgantiA Zanchetti
Sep 1, 1985·Pflügers Archiv : European journal of physiology·T NakashimaM Shibata
Jan 1, 1969·Pflügers Archiv : European journal of physiology·L C Senay
Dec 1, 1983·Canadian Journal of Physiology and Pharmacology·P A Stewart
Dec 1, 1981·Respiration Physiology·I E Alexander, E R Lumbers

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Citations

Jul 1, 1993·Respiration Physiology·D B Jennings
Aug 13, 1993·Regulatory Peptides·J C McKirdyD B Jennings
Jan 16, 2003·The Journal of Physiology·Zoltán MolnárAndrás Spät
Feb 13, 2007·Respiratory Physiology & Neurobiology·Prem Kumar, Ismaeel Bin-Jaliah
Oct 16, 2001·Canadian Journal of Physiology and Pharmacology·D B Jennings
Nov 14, 2003·Canadian Journal of Physiology and Pharmacology·A P Heenan, L A Wolfe
Sep 1, 1994·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·D B Jennings

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