Acute Changes in Plasma Total Tau Levels Are Independent of Subconcussive Head Impacts in College Football Players

Journal of Neurotrauma
Keisuke KawataDianne Langford

Abstract

Athletes in contact sports sustain repetitive subconcussive head impacts in a brief window, yet neurophysiological sequelae from repetitive subconcussion remain unclear. This prospective longitudinal study examined a relationship between changes in plasma Tau protein levels and subconcussive impact kinematic data in 23 Division I collegiate football players during a series of pre-season practices. Plasma measures for Tau and S100β proteins, symptom scores, and near point of convergence were obtained at pre-season baseline and pre-/post-practices. During each practice, impact frequency and linear and rotational head accelerations were recorded via an accelerometer-embedded mouth guard. There were significant elevations in plasma Tau levels at all post-practice time-points, compared with those of pre-practice and baseline levels. However, the highest degree of elevation in plasma Tau was observed after the first practice, for which players sustained the lowest number of hits and magnitudes for these hits. Subconcussive impact exposure during practice (e.g., head impact frequency and magnitude) did not predict increased plasma Tau levels. Concussion history and years of football experience also were unrelated to changes in plasma ...Continue Reading

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Citations

Apr 27, 2019·Frontiers in Neurology·Steven W ZonnerKeisuke Kawata
Mar 3, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Cody A C LustDavid W L Ma
Jul 5, 2018·Frontiers in Neurology·Tharmegan TharmaratnamTaylor A Tabobondung
Feb 26, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Matthew I HiskensAndrew S Fenning
Feb 26, 2020·Brain Injury : [BI]·Stian Bahr SandmoRoald Bahr

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SAS

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