PMID: 9184261May 1, 1997Paper

Acute changes in serum calcium and parathyroid hormone circulating levels induced by the oral intake of five currently available calcium salts in healthy male volunteers

Clinical Rheumatology
R DeroisyJ Y Reginster

Abstract

Several calcium supplements are currently available and many of them are marketed without proper comparison of the bioavailability of the actual preparations. The aim of the present trial was to evaluate and compare the acute changes in serum calcium (Ca) and parathyroid hormone (PTH) levels following the oral administration of a vehicle and of five calcium salts currently prescribed in Western Europe. No significant changes in serum Ca or PTH levels were observed after administration of the vehicle. All calcium salts induced significant increases in serum Ca and decreases in serum PTH compared to baseline values. Comparison of the six response curves revealed a significantly greater increase in serum Ca and a greater decrease in serum PTH after each of the calcium salts than observed after the vehicle. However, no statistically significant differences were observed between the different calcium salts for serum Ca increments. The decrease in serum PTH observed after administration of an ossein-hydroxyapatite complex was significantly less important than after the four other calcium salts, even if statistically different than after vehicle. When assessing the area under the curve (AUC) of PTH values, we observed that calcium car...Continue Reading

References

Dec 3, 1992·The New England Journal of Medicine·M C ChapuyP J Meunier
Jul 19, 1992·The New England Journal of Medicine·C C JohnstonM Peacock
Feb 1, 1991·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R P Heaney
Sep 1, 1991·The Journal of Clinical Endocrinology and Metabolism·P J EldersP F van der Stelt
Feb 1, 1991·Journal of the American Geriatrics Society·G KochersbergerK W Lyles
May 1, 1990·Calcified Tissue International·R P HeaneyC M Weaver
Apr 21, 1990·BMJ : British Medical Journal·B E Nordin, R P Heaney
Sep 1, 1990·Journal of Gerontology·G KochersbergerK W Lyles
Sep 27, 1990·The New England Journal of Medicine·B Dawson-HughesS Tannenbaum
Jan 21, 1989·BMJ : British Medical Journal·J A Kanis, R Passmore
Jan 1, 1987·Calcified Tissue International·X MarchandiseJ L Wemeau
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J Y ReginsterP Franchimont
Apr 1, 1986·Australian and New Zealand Journal of Medicine·I R ReidH K Ibbertson
Aug 27, 1987·The New England Journal of Medicine·M S SheikhJ S Fordtran
Aug 1, 1985·The Journal of Clinical Endocrinology and Metabolism·M J Nicar, C Y Pak
Dec 5, 1985·The New England Journal of Medicine·K Godfrey
Sep 1, 1969·The Journal of Clinical Investigation·S J BirgeG D Whedon
Nov 1, 1994·Calcified Tissue International·R S YangK S Tsai
Jun 1, 1994·Calcified Tissue International·H RicoI Arribas
Sep 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Y ReginsterP Franchimont

❮ Previous
Next ❯

Citations

Jul 21, 1998·Endocrinology and Metabolism Clinics of North America·I R Reid
Oct 4, 2011·Allergologia et immunopathologia·R NúñezM Boquete
Mar 7, 2007·Allergologia et immunopathologia·J Domínguez-OrtegaC Kindelan
Sep 20, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Morton G BurtCarolyn J Petersons
Jun 30, 2016·Archives of Endocrinology and Metabolism·Guilherme Alcantara Cunha LimaMaria Lucia Fleiuss de Farias
May 22, 2013·The Journal of Clinical Endocrinology and Metabolism·Natalie E CusanoJohn P Bilezikian
Mar 28, 2019·Aging Clinical and Experimental Research·Manju ChandranAmbrish Mithal
Jan 23, 1999·The Journal of Nutrition·F Bronner, D Pansu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.