Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis

The Journal of Infectious Diseases
Shih-Min WangChing-Chuan Liu

Abstract

Brainstem encephalitis (BE) is a serious neurological complication of enterovirus 71 (EV71) infection. The present study was designed to determine the characteristics of the chemokine response in the blood and cerebrospinal fluid (CSF) of patients with EV71-associated BE. Thirty-one patients with BE were studied. They consisted of 12 with uncomplicated BE, 9 with autonomic nervous system (ANS) dysregulation, and 10 with pulmonary edema (PE); 13 healthy control subjects were also studied. Plasma and CSF concentrations of various chemokines were determined by a particle-based flow cytometry immunoassay. Plasma levels of interferon (IFN)-gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, monokine induced by IFN-gamma (MIG), and interleukin (IL)-8 were significantly higher in patients with PE than in those with uncomplicated BE. CSF levels of MIG were significantly higher in patients with PE than in those with uncomplicated BE and ANS dysregulation. The ratios of mean CSF to plasma levels for MCP-1 and IL-8 were highest in patients with uncomplicated BE and tended to fall with increasing severity of the disease. Overexpression of the chemokine cascade in the central nervous system compartment appears to play a...Continue Reading

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Citations

Dec 31, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ruchi SrivastavaUsha Kant Misra
Feb 15, 2013·Medical Microbiology and Immunology·I-Chun ChenChing-Chuan Liu
Oct 11, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S-M WangC-C Liu
Jun 1, 2013·Journal of the Pediatric Infectious Diseases Society·Soren GanttSteven G Self
Apr 20, 2014·Journal of Biomedical Science·Ya-Fang Wang, Chun-Keung Yu
Mar 13, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ji-an LiZhen-liang Han
Jun 28, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Anamarija CavčićSnježana Židovec Lepej
Mar 30, 2010·Microbes and Infection·Kuo-Feng WengShin-Ru Shih
Aug 12, 2014·Virology·Fang-Hsiu ShenShun-Hua Chen
Sep 8, 2012·Clinical & Developmental Immunology·Shih-Min WangChing-Chuan Liu
Aug 16, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hong-Tao ZhouXiao-Yan Che
Aug 8, 2015·PloS One·Yu-Ting LiaoChing-Chuan Liu
Jun 18, 2016·Mediators of Inflammation·Tobias DahmTobias Tenenbaum
Aug 26, 2015·The American Journal of Tropical Medicine and Hygiene·Mao-Zhong LiZhao-Jun Duan
Mar 4, 2014·Expert Review of Anti-infective Therapy·Shih-Min Wang, Ching-Chuan Liu

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