Acute cholinergic rescue of synaptic plasticity in the neurodegenerating cortex of anti-nerve-growth-factor mice

The European Journal of Neuroscience
Emanuele PesaventoAntonino Cattaneo

Abstract

Deficits in cholinergic systems innervating cerebral cortex are associated with cognitive impairment during senescence and in age-related neurodegenerative pathologies. However, little is known about the role of cholinergic pathways in modulating cortical plasticity. Basal forebrain cholinergic neurons are a major target for nerve-growth factor (NGF). In order to investigate the relationship between cholinergic innervation and cortical synaptic plasticity, we exploited a transgenic mouse model in which the activity of NGF in the adult nervous system is neutralized by the expression of blocking antibodies to NGF itself (anti-NGF mice) [Ruberti, F. et al. (2000). J. Neurosci. 20, 2589-2601]. In 6-month-old anti-NGF mice, we show that the reduction in cholinergic innervation of the cortex is associated with different forms of synaptic plasticity impairment. A local, acute increase in the availability of acetylcholine rescues these synaptic plasticity deficits, thus indicating that a cholinergic system mediates the impairment of cortical plasticity at this early stage of the neurodegenerative process triggered by NGF neutralization. Our results represent an important step in unveiling the pivotal role of cholinergic transmission in...Continue Reading

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Citations

Sep 1, 2006·Cellular and Molecular Neurobiology·Simona Capsoni, Antonino Cattaneo
Nov 3, 2010·Molecular Neurobiology·Enrico CherubiniLaura Lagostena
Aug 12, 2004·Biological & Pharmaceutical Bulletin·Jinyoung HurSun Yeou Kim
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Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paola Giusti-RodríguezLi-Huei Tsai
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Roberta De RosaAntonino Cattaneo
Jul 30, 2014·Life Sciences· NehaNirmal Singh
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Jan 12, 2010·Behavioural Brain Research·Antonio Contestabile
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Oct 3, 2002·Molecular and Cellular Neurosciences·Simona CapsoniAntonino Cattaneo

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