Acute Citrulline-Malate Supplementation and High-Intensity Cycling Performance

Journal of Strength and Conditioning Research
Brian CunniffeMarco Cardinale

Abstract

Cunniffe, B, Papageorgiou, M, O'Brien, B, Davies, NA, Grimble, GK, and Cardinale, M. Acute citrulline-malate supplementation and high-intensity cycling performance. J Strength Cond Res 30(9): 2638-2647, 2016-Dietary L-citrulline-malate (CM) consumption has been suggested to improve skeletal muscle metabolism and contractile efficiency, which would be expected to predispose exercising individuals to greater fatigue resistance. The purpose of this study was to examine the effects of CM supplementation on acid-base balance and high-intensity exercise performance. In a double-blind, placebo-controlled, crossover study, 10 well-trained males consumed either 12 g of CM (in 400 ml) or lemon sugar-free cordial (placebo [PL]) 60 minutes before completion of 2 exercise trials. Each trial consisted of subjects performing 10 (×15 seconds) maximal cycle sprints (with 30-second rest intervals) followed by 5 minutes recovery before completing a cycle time-to-exhaustion test (TTE) at 100% of individual peak power (PP). Significant increases in plasma concentrations of citrulline (8.8-fold), ornithine (3.9-fold), and glutamine (1.3-fold) were observed 60 minutes after supplementation in the CM trial only (p ≤ 0.05) and none of the subjects expe...Continue Reading

References

Aug 1, 1974·Journal of Applied Physiology·D B Dill, D L Costill
Mar 1, 1997·Canadian Journal of Physiology and Pharmacology·F GoubelJ M Gillardin
Jan 12, 2001·Physiological Reviews·J S Stamler, G Meissner
Jul 30, 2002·British Journal of Sports Medicine·D BendahanP J Cozzone
May 6, 2004·Medicine and Science in Sports and Exercise·David BishopCarmel Goodman
May 21, 2005·International Journal of Sport Nutrition and Exercise Metabolism·Robert RobergsJason Siegler
Dec 6, 2005·International Journal of Sport Nutrition and Exercise Metabolism·Gulshanara BegumMichael Leveritt
May 9, 2006·Medicine and Science in Sports and Exercise·Robert C HicknerMichael McCammon
May 22, 2007·The Journal of Nutrition·George K Grimble
Jul 31, 2007·British Journal of Clinical Pharmacology·Edzard SchwedhelmRainer H Böger
Nov 28, 2008·European Journal of Pharmacology·Benoît GiannesiniDavid Bendahan
Oct 27, 2009·European Journal of Applied Physiology·Juan Del CosoRicardo Mora-Rodriguez
Nov 26, 2009·Journal of Strength and Conditioning Research·Kaitlin M SweeneyScott T Doberstein
Apr 14, 2010·Journal of Strength and Conditioning Research·Joaquín Pérez-Guisado, Philip M Jakeman
May 26, 2010·European Journal of Applied Physiology·Antoni SuredaAntoni Pons
Jun 15, 2011·European Journal of Pharmacology·Benoît GiannesiniDavid Bendahan
Sep 13, 2011·Journal of Nutritional Science and Vitaminology·Kohei TakedaTohru Takemasa
Aug 14, 2012·Journal of Science and Medicine in Sport·Bryan SaundersCaroline Sunderland
Jul 19, 2013·Journal of Agricultural and Food Chemistry·Martha P Tarazona-DíazEncarna Aguayo
Sep 17, 2014·Journal of Strength and Conditioning Research·Benjamin WaxJoseph Sperlak
Dec 18, 2014·Journal of Sports Sciences·Paul T CutrufelloGerald S Zavorsky
May 30, 2015·Journal of Applied Physiology·Stephen J BaileyAndrew M Jones

❮ Previous
Next ❯

Citations

Aug 3, 2018·Journal of the International Society of Sports Nutrition·Chad M KerksickRichard B Kreider
Jan 25, 2020·Journal of Strength and Conditioning Research·Adam M Gonzalez, Eric T Trexler
Dec 7, 2017·Journal of Strength and Conditioning Research·Adam M GonzalezGerald T Mangine
Aug 12, 2018·Journal of the International Society of Sports Nutrition·Andrew J ChappellTrevor Simper
Feb 26, 2020·Journal of the International Society of Sports Nutrition·Jeffrey M RogersMichelle Gray
Nov 28, 2017·Journal of Strength and Conditioning Research·Tyler M FarneyDassy A Salazar
Nov 5, 2019·Nutrición hospitalaria·Álvaro Huerta OjedaGuillermo Barahona-Fuentes
May 20, 2021·International Journal of Sport Nutrition and Exercise Metabolism·Fredrik Tonstad VårvikAdam M Gonzalez
Aug 22, 2021·European Journal of Applied Physiology·Lewis A GoughCraig A Bridge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.