Acute coagulation disorder in a critically ill patient - A case report

Journal of the Intensive Care Society
Agnes OberhuberGriesmacher Andrea

Abstract

A 79-year-old critically ill woman presented with remarkable prolongation of activated partial thromboplastin time and thrombin time combined with high levels of anti-factor IIa activity 26 days after coronary artery bypass grafting. Coagulation disorder was associated with severe bleeding. Cause of coagulopathy was accidental administration of argatroban in an unknown dosage. Clearance of argatroban was significantly prolonged because of a liver function disorder related to septic multiorgan failure. Argatroban reversal was performed with prothrombin complex concentrate.

References

Nov 1, 1993·British Journal of Haematology·H BänningerM Furlan
Aug 19, 2003·The Annals of Pharmacotherapy·Simon de Denus, Sarah A Spinler
Feb 2, 2006·The Annals of Pharmacotherapy·Andrew J Yee, David J Kuter
May 22, 2010·Critical Care : the Official Journal of the Critical Care Forum·Bernd SaugelWolfgang Huber
Oct 27, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Walter-Michael HalbmayerAndrea Griesmacher
Apr 3, 2015·Thrombosis and Haemostasis·Andreas GreinacherKathleen Selleng

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Methods Mentioned

BETA
coronary artery bypass

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