Acute cold stress in rheumatoid arthritis inadequately activates stress responses and induces an increase of interleukin 6

Annals of the Rheumatic Diseases
R H StraubMarjatta Leirisalo-Repo

Abstract

Acute stress in patients with rheumatoid arthritis (RA) should stimulate a strong stress response. After cryotherapy, we expected to observe an increase of hormones of the adrenal gland and the sympathetic nervous system. A total of 55 patients with RA were recruited for whole-body cryotherapy at -110 degrees C and -60 degrees C, and local cold therapy between -20 degrees C and -30 degrees C for 7 days. We measured plasma levels of steroid hormones, neuropeptide Y (sympathetic marker), and interleukin (IL)6 daily before and after cryotherapy. In both therapy groups with/without glucocorticoids (GC), hormone and IL6 levels at baseline and 5 h after cold stress did not change over 7 days of cryotherapy. In patients without GC, plasma levels of cortisol and androstenedione were highest after -110 degrees C cold stress followed by -60 degrees C or local cold stress. The opposite was found in patients under GC therapy, in whom, unexpectedly, -110 degrees C cold stress elicited the smallest responses. In patients without GC, adrenal cortisol production increased relative to other adrenal steroids, and again the opposite was seen under GC therapy with a loss of cortisol and an increase of dehydroepiandrosterone. Importantly, there was...Continue Reading

Citations

Aug 5, 2009·Zeitschrift für Rheumatologie·J Hermann
Jul 14, 2009·Arthritis Research & Therapy·Rainer H Straub, Joachim R Kalden
May 19, 2010·Arthritis Research & Therapy·Sabine J M de BrouwerAndrea W M Evers
Feb 14, 2016·Modern Rheumatology·Kensuke KoyamaHirotaka Haro
Nov 5, 2011·Medical Hypotheses·Katherine L Molnar-Kimber, Charles T Kimber
Nov 18, 2015·BioMed Research International·Małgorzata GizińskaAnna Straburzyńska-Lupa
Dec 19, 2013·Expert Review of Clinical Immunology·Xavier GuillotDaniel Wendling
Dec 15, 2020·Pain and Therapy·Carol GarciaAlaa Abd-Elsayed
Feb 26, 2021·Journal of Thermal Biology·Sławomir KujawskiPaweł Zalewski

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