Acute Consumption of Prebiotic Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate, but not from Ferrous Sulfate and Ferric Pyrophosphate: Stable Iron Isotope Studies in Iron-Depleted Young Women

The Journal of Nutrition
Frederike M D JeroenseIsabelle Herter-Aeberli

Abstract

Although acute consumption of high doses of prebiotic galacto-oligosaccharides (GOS) increases fractional iron absorption (FIA) from ferrous fumarate (FeFum), it is uncertain if low doses of GOS have this effect. Furthermore, whether GOS improve iron absorption from other commonly used iron compounds and whether ascorbic acid (AA) enhances the effect of GOS on iron absorption from FeFum is unclear. In iron-depleted women [serum ferritin (SF) <30 μg/L], we assessed: 1) whether the acute enhancing effect of GOS on FeFum is dose dependent; 2) if GOS would affect FIA from ferrous sulfate (FeSO4) or ferric pyrophosphate (FePP); and 3) if AA and GOS given together enhance FIA from FeFum to a greater extent compared with GOS alone. We recruited 46 women (mean age 22.0 y, mean BMI 21.3 kg/m2, median SF 17.1 μg/L), and measured FIA from 14 mg iron labeled with stable isotopes in the following conditions: 1) FIA from FeFum given with 3.5 g, 7 g GOS, and without GOS; 2) FIA from FeSO4 and FePP given with and without 15 g GOS; and 3) FIA from FeFum given with 7 g GOS with and without 93 mg AA. FIA was measured as erythrocyte incorporation of stable isotopes after 14 d. Comparisons were made using paired samples t-test or Wilcoxon rank sum ...Continue Reading

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References

Jan 1, 1967·The Journal of Clinical Investigation·F HosainC A Finch
Jan 1, 1980·Annals of the New York Academy of Sciences·S R Lynch, J D Cook
Mar 13, 1998·The American Journal of Clinical Nutrition·E G van den HeuvelW van Dokkum
Feb 16, 1999·The American Journal of Clinical Nutrition·E K LundI T Johnson
Apr 2, 2002·The Journal of Nutrition·Richard F Hurrell
Feb 5, 1963·Biochimica Et Biophysica Acta·P J CHARLEYP SALTMAN
Dec 4, 2003·The British Journal of Nutrition·Meredith C FidlerRichard F Hurrell
Mar 4, 2005·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Birgit TeucherHéctor Cori
Mar 5, 2010·The American Journal of Clinical Nutrition·Richard Hurrell, Ines Egli
Aug 28, 2010·Nutrition Reviews·Richard Hurrell
Oct 22, 2010·The American Journal of Clinical Nutrition·Michael B ZimmermannRichard F Hurrell
Oct 18, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Karin HotzThomas Walczyk
Dec 13, 2016·European Journal of Nutrition·Tatiana ChristidesPaul Anthony Sharp
Oct 27, 2017·The American Journal of Clinical Nutrition·Daniela Paganini, Michael B Zimmermann
Sep 12, 2018·Maternal & Child Nutrition·Jillian L WaidSheela S Sinharoy
Jun 20, 2019·Frontiers in Nutrition·Gonçalo N MartinsAndrea Gomez-Zavaglia
Sep 1, 2010·Comprehensive Reviews in Food Science and Food Safety·Duarte P M TorresLígia R Rodrigues

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