Acute coronary syndrome secondary to allergic coronary vasospasm (Kounis Syndrome): a case series, follow-up and literature review

BMC Cardiovascular Disorders
Jing LiWenhua Peng

Abstract

Kounis syndrome (KS) is the concurrence of acute coronary syndrome associated with mast-cell and platelet activation in the setting of hypersensitivity and allergic or anaphylactic insults. Many drugs and environmental exposures had been reported as inducers, but various inducers and the mechanism of KS remained unknown till now. The widely used traditional Chinese medicine (TCM) as a potential sensitizer were scarcely reported to induce allergic vasospasm due to the ignorance of the linkage between traditional medicine allergy and vasospasm. We described 5 rare cases of KS including unreported triggers of TCM and abortion, reported the treatment strategy and 1~4 years' follow-up results, and tried to probe into the etiology of KS. Case 1 and case 2 for the first time reported acute ST-segment elevation myocardial infarction (STEMI) caused by Chinese herbs related allergic coronary vasospasm. Case 3 reported recurrent angina following allergen contact and wheezing, indicating the internal linkage of coronary vasospasm and allergic asthma. Case 4 described a childbearing-age woman suffered refractory ischemic chest pain due to coronary vasospasm in a special period of post-abortion, the attacks suddenly disappeared when her meno...Continue Reading

References

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Citations

Jul 1, 2020·Terapevticheskiĭ arkhiv·B L ShklovskiyV I Baksheev
Jun 14, 2019·Proceedings·Waiel AbusninaFuad Zeid
Feb 6, 2021·Journal of Thrombosis and Thrombolysis·Pei Zheng TanPeter Chang
Dec 29, 2020·International Journal of General Medicine·Haoyu WuLei Liang

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