Acute Coronary Syndrome With Immune Checkpoint Inhibitors: A Proof-of-Concept Case and Pharmacovigilance Analysis of a Life-Threatening Adverse Event

The Canadian Journal of Cardiology
Jennifer CautelaFranck Thuny

Abstract

Isolated cases of acute coronary syndrome (ACS) associated with immune checkpoint inhibitors (ICIs) have been described without the establishment of a formal cause-and-effect relationship between treatment and adverse event. We reported a case of ACS after the first administration of an ICI and with a fatal recurrence in another coronary area immediately after readministration. According to guidelines, causality was considered to be certain. Subsequently, we queried the French pharmacovigilance database and found 4 cases of ACS with coronary artery thrombosis. Causality was probable in those patients. These data suggest that ACS may be another life-threatening cardiac adverse event occurring with ICI exposure.

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Citations

Nov 18, 2020·Journal of Clinical Medicine·Valentina MilazzoGiancarlo Marenzi
Dec 11, 2020·Journal for Immunotherapy of Cancer·Jennifer CautelaFranck Thuny
Jul 19, 2021·The American Journal of Emergency Medicine·Demis N LipePatrick Chaftari
Sep 17, 2021·European Heart Journal·Charles DolladilleJoachim Alexandre

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