Acute correction of electromechanical dyssynchrony and response to cardiac resynchronization therapy.

ESC Heart Failure
Ghassan MoubarakFrédéric Anselme

Abstract

Echocardiographic measures of dyssynchrony at baseline have not demonstrated a good ability to predict response to cardiac resynchronization therapy (CRT). The purpose of this study was to determine if the acute correction of electromechanical dyssynchrony, assessed by the change in simple pulsed-Doppler measures, was related to CRT response at 6 months. Echocardiography was performed at baseline and at pre-discharge after CRT implantation. Intraventricular, interventricular, and atrioventricular dyssynchrony were evaluated by the left pre-ejection interval (LPEI), the interventricular mechanical delay, and the ratio of left ventricular filling time to RR interval, respectivelxy. A patient was considered responder if he/she was alive without hospitalization for heart failure and had an absolute increase of left ventricular ejection fraction (LVEF) >5 points. Forty-eight patients (mean age 67 ± 11 years, 73% male, mean LVEF 30 ± 5%) were included. CRT led to an acute correction of intraventricular and interventricular dyssynchrony but not to an acute correction of atrioventricular dyssynchrony. There were 31 (65%) responders at 6 months. Two factors were independently associated with CRT response in multivariate analysis: ischem...Continue Reading

References

Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
May 7, 2008·Circulation·Eugene S ChungJaime Murillo
Jan 27, 2009·European Heart Journal·Gerhard WikstromUNKNOWN CARE-HF study investigators
Sep 3, 2009·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-CRT Trial Investigators
Apr 27, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Chun-Li WangChi-Tai Kuo
Jul 28, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Patricia ReantStephane Lafitte
Apr 8, 2014·Archives of Cardiovascular Diseases·Ghassan MoubarakSerge Cazeau
Mar 5, 2016·Journal of the American College of Cardiology·Jeanne E PooleUlrika Birgersdotter-Green
Oct 25, 2016·The American Journal of Cardiology·Panagiotis KorantzopoulosTong Liu
May 3, 2018·Echocardiography·Donato MeleMatteo Bertini
Feb 12, 2019·Open Heart·Serge CazeauJulien Reygner

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