Acute critical illness and cancer risk: Implications from a nationwide population based study in Asia

International Journal of Cardiology
Wei-Syun Hu, Cheng-Li Lin

Abstract

The objective of this study was to identify the risk of incident cancer among patients with acute critical illness. The study applied the big database from the National Health Research Institutes in Taiwan. The risk of incident cancer over a 12-year period in patients with 4 types of newly diagnosed acute critical illness (septicemia/septic shock, acute myocardial infarction, hemorrhagic stroke and ischemic stroke) was investigated using Cox proportional hazards regression model with further controlling for the competing risk of death. This study included 42,675 patients in the acute critical illness cohort and 42,675 patients in the age- and sex-matched comparison cohort. Correlation between the incidence of cancer and critical illness was found after adjusting for age, sex, comorbidities and further controlling for death [adjusted subhazard ratio (aSHR) = 1.73, 95% confidence interval (CI) = 1.63-1.84]. Five common incident cancers associated with acute critical illness were hematologic malignancy (aSHR = 4.00, 95% CI = 3.11-5.14), cancers of liver (aSHR = 2.25, 95% CI = 1.93-2.63), uterus (aSHR = 1.86, 95% CI = 1.32-2.61), head and neck (aSHR = 1.79, 95% CI = 1.39-2.30) and esophagus (aSHR = 1.62, 95% CI = 1.09-2.42). Among ...Continue Reading

Citations

Mar 20, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Guillaume MonneretFabienne Venet
Nov 17, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Bastien RiouxLaura C Gioia

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