Acute cytomegalovirus infection and IgM anti-GM2 antibody

Journal of the Neurological Sciences
N Yuki, Y Tagawa

Abstract

Guillain-Barré syndrome (GBS) sometimes is preceded by cytomegalovirus (CMV) infection. Irie et al. (J. Neuroimmunol. 1996;68:19-26) reported that three patients with GBS subsequent to CMV infection had IgM and IgG anti-GM2 antibodies. In our larger study, the IgMs from the CMV-associated GBS patients showed significantly higher anti-GM2 antibody titers than anti-GM3, anti-GD1a, anti-GD1b, anti-GD2, anti-GD3, anti-GT1b, anti-GQ1b, and anti-SGPG antibody titers. None of the anti-glycosphingolipid antibody titers differed significantly from the others in the IgGs from the CMV-associated GBS patients. However, IgM anti-GM2 antibody frequently was present in GBS patients who were not preceded by CMV infection and non-GBS patients with acute CMV infection. Our results did not support the conclusion of Irie et al. that anti-GM2 antibodies were closely associated with acute CMV infection in GBS, but acute CMV infection, with and without GBS, was associated with IgM anti-GM2 antibody.

Citations

Jun 12, 1999·Muscle & Nerve·Y TakiyamaS Kusunoki
Jul 28, 2009·Journal of Neurology·Keiichiro SusukiNobuhiro Yuki
Jun 22, 1999·Journal of Neuroimmunology·B CavannaE Nobile-Orazio
Mar 1, 2000·Journal of Neuroimmunology·R A HughesK J Smith
Mar 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael Lunn, Richard Hughes
Oct 19, 1999·Microbiology and Immunology·N Okada, H Okada
Mar 1, 2011·Journal of Veterinary Internal Medicine·N HoltM R Lappin
Sep 20, 2000·Ugeskrift for laeger·C Krarup, S Vorstrup
Oct 2, 2008·Internal Medicine·Daigoro HirohamaToshio Mizutani
Feb 13, 2001·Journal of Neuroimmunology·K KaidaI Kanazawa
Dec 2, 2015·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Carlotta SpagnoliCarlo Fusco
Jan 4, 2013·Journal of the Peripheral Nervous System : JPNS·Helmar C LehmannHans-Peter Hartung
Oct 21, 2016·Expert Review of Clinical Immunology·Anil K JastiM Eric Gershwin
Mar 22, 2007·Muscle & Nerve·Nobuhiro Yuki
Jan 30, 2018·Cellular & Molecular Immunology·Yhojan RodríguezJuan-Manuel Anaya
Aug 26, 2011·Expert Review of Neurotherapeutics·Nortina Shahrizaila, Nobuhiro Yuki
May 17, 2013·Internal Medicine·Satoshi OkawaHirohide Ohnishi
Aug 1, 2013·Expert Review of Clinical Immunology·Benjamin R Wakerley, Nobuhiro Yuki
Dec 16, 1998·Current Opinion in Neurology·H P HartungJ D Pollard
Apr 8, 2019·Journal of Neurology·Michiaki KogaTakashi Kanda
Jul 5, 2018·Journal of Clinical Neurology·Jong Kuk KimJong Seok Bae

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