Acute dapsone intoxication: a case treated with continuous infusion of methylene blue, forced diuresis and plasma exchange

Journal of Toxicology. Clinical Toxicology
G BerlinJ Mårtensson

Abstract

A case of massive dapsone poisoning (15 g) in a 26 year old man is reported. The patient exhibited high plasma dapsone concentration, marked methemoglobinemia, and signs of hemolysis. He recovered completely after intensive treatment with methylene blue, activated charcoal, forced diuresis, and plasma exchange. In order to avoid overdosage of methylene blue it is concluded that this substance should be given by continuous intravenous infusion in cases with severe methemoglobinemia. This way of administration caused a steady decrease in the methemoglobin concentration compared to intermittent administration. Plasma exchange was of minor benefit, probably due to the large distribution volume of dapsone.

References

Jan 1, 1979·Clinical Toxicology·E ElonenM J Mattila
Apr 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·R W Riley, L Levy
Apr 1, 1974·The British Journal of Dermatology·G A EllardR S Tan
Dec 1, 1970·The British Journal of Dermatology·J O AlexanderE M Meredith
Mar 1, 1971·Clinical Pharmacology and Therapeutics·R GelberL Levy
Oct 1, 1983·Australian and New Zealand Journal of Medicine·Z H EndreL Woodbridge
Mar 1, 1982·Journal of Toxicology. Clinical Toxicology·M LambertA Hassoun
Dec 1, 1982·Journal of Toxicology. Clinical Toxicology·J R ReigartJ M Lindsey
Jun 1, 1980·Clinical Pharmacology and Therapeutics·P J NeuvonenM J Mattila
Oct 1, 1980·The British Journal of Ophthalmology·D J KennerG H Chester
Jan 1, 1959·Scandinavian Journal of Clinical and Laboratory Investigation·M HARBOE

❮ Previous
Next ❯

Citations

Apr 14, 2011·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Joshua Canning, Michael Levine
Jun 1, 1995·Journal of Accident & Emergency Medicine·R J Edwards, J Ujma
Jul 1, 1987·Medical Toxicology and Adverse Drug Experience·A JaegerF Flesch
Mar 4, 2006·Archives of Medical Research·Shahin ShadniaMohammad Abdollahi
Jul 19, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Marc GhannoumJosée Bouchard
Aug 20, 2011·The Annals of Pharmacotherapy·James A BarclayRami B Ibrahim
Mar 30, 2000·Lasers in Surgery and Medicine·J F BirchP R Bell
Jul 6, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Subramanian SenthilkumaranPonniah Thirumalaikolundusubramanian
Apr 1, 2008·Indian Journal of Pediatrics·Rajniti PrasadMadhukar Pandey
Oct 10, 2007·Clinical Pharmacokinetics·Darren M Roberts, Nick A Buckley
Sep 1, 1989·Medical Toxicology and Adverse Drug Experience·A H Dawson, I M Whyte
Jul 3, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Bernard J BrabinFrancine Verhoeff
May 24, 2020·Neurocritical Care·Sherif Hanafy MahmoudTheresa Human
Oct 26, 1999·Annals of Emergency Medicine·R O WrightA D Woolf

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.