Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle priming

Nature Neuroscience
Josefin SnellmanDavid Zenisek


In vision, balance and hearing, sensory receptor cells translate sensory stimuli into electrical signals whose amplitude is graded with stimulus intensity. The output synapses of these sensory neurons must provide fast signaling to follow rapidly changing stimuli while also transmitting graded information covering a wide range of stimulus intensity and must be able to sustain this signaling for long time periods. To meet these demands, specialized machinery for transmitter release, the synaptic ribbon, has evolved at the synaptic outputs of these neurons. We found that acute disruption of synaptic ribbons by photodamage to the ribbon markedly reduced both sustained and transient components of neurotransmitter release in mouse bipolar cells and salamander cones without affecting the ultrastructure of the ribbon or its ability to localize synaptic vesicles to the active zone. Our results indicate that ribbons mediate both slow and fast signaling at sensory synapses and support an additional role for the synaptic ribbon in priming vesicles for exocytosis at active zones.


Jul 27, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Caixia LvDavid Zenisek
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miao TianRichard H Kramer
May 10, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thirumalini VaithianathanGary Matthews
Dec 15, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew J Van Hook, Wallace B Thoreson
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lavinia SheetsTeresa Nicolson
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minghui ChenWallace B Thoreson
Jun 19, 2013·Journal of Visualized Experiments : JoVE·Matthew J Van Hook, Wallace B Thoreson
Jun 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Thirumalini Vaithianathan, Gary Matthews
Jun 22, 2012·Annual Review of Neuroscience·Saaid SafieddineChristine Petit
Mar 6, 2013·The Journal of Physiology·Mean-Hwan KimHenrique von Gersdorff
Nov 21, 2012·Trends in Neurosciences·Stefan Hallermann, R Angus Silver
Oct 15, 2014·The Journal of General Physiology·Matthew J Van HookWallace B Thoreson
Sep 2, 2011·Acta Physiologica·Hanna Regus-Leidig, Johann H Brandstätter
Jun 22, 2013·The Journal of Comparative Neurology·Albena KantardzhievaWilliam F Sewell
Jun 9, 2012·The Journal of Comparative Neurology·Michaela FuchsJohann H Brandstätter
May 15, 2012·Progress in Retinal and Eye Research·Wallace B Thoreson, Stuart C Mangel
Apr 16, 2015·Cell and Tissue Research·Carolin Wichmann, Tobias Moser
Oct 15, 2011·Current Biology : CB·Ilaria Pelassa, Leon Lagnado
Jun 12, 2012·Cell Calcium·Mark A Rutherford, Tina Pangrsic
Jul 11, 2012·Cell Calcium·Soyoun Cho, Henrique von Gersdorff
Jun 28, 2014·Frontiers in Cellular Neuroscience·Manuel Castellano-Muñoz, Anthony J Ricci
Mar 8, 2016·Scientific Reports·Elisa D'EsteStefan W Hell
Aug 2, 2018·Physiological Reviews·Tina PangrsicAlexandra Koschak
Sep 17, 2016·F1000Research·Tobias Moser, Christian Vogl
Apr 17, 2014·Visual Neuroscience·Karlene M Cork, Wallace B Thoreson
Sep 1, 2011·Nature Neuroscience·Jeffrey S Diamond
Jun 8, 2019·ELife·Justin J GrassmeyerWallace B Thoreson
Apr 17, 2012·Physiology·A V Bulankina, Tobias Moser
May 1, 2013·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Tobias MoserArnold Starr
Aug 3, 2019·Physiological Reviews·Tobias MoserFrank Schmitz


Feb 24, 1994·Nature·Henrique von Gersdorff, G Matthews
Oct 6, 1994·Nature·Ruth HeidelbergerG Matthews
Mar 7, 1998·The Journal of General Physiology·Ruth Heidelberger
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·T SurreyS Leibler
Feb 22, 2001·Annual Review of Physiology·G W Davis, I Bezprozvanny
Sep 6, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Lenzi, Henrique von Gersdorff
Mar 22, 2002·Pflügers Archiv : European journal of physiology·Stuart L JohnsonCorné J Kros
Apr 27, 2002·The Journal of Comparative Neurology·Ulrike GrünertHeinz Wässle
Jul 2, 2002·Journal of Neurophysiology·Ruth HeidelbergerGary Matthews
Apr 19, 2003·The Journal of Physiology·Margaret Lin VerukiEspen Hartveit
Jul 6, 2004·Nature Neuroscience·Joshua H SingerJeffrey S Diamond
Nov 5, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David ZenisekGary Matthews
May 6, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katalin RablWallace B Thoreson
May 10, 2005·Nature Cell Biology·Matteo BonazziAlberto Luini
Feb 3, 2006·Journal of Neurophysiology·Joshua H Singer, Jeffrey S Diamond
Jun 26, 2007·Methods in Cell Biology·Diane Hoffman-KimDaniel G Jay
Sep 8, 2007·The Journal of Physiology·Michael R CogginsDavid Zenisek
Sep 11, 2007·Nature Neuroscience·Mitsuharu MidorikawaMasao Tachibana
Mar 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·David Zenisek
Mar 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lisamarie LoGiudiceGary Matthews
Jul 12, 2008·Nature Structural & Molecular Biology·Josep Rizo, Christian Rosenmund
Dec 30, 2008·Visual Neuroscience·Sue-Yeon ChoiRichard H Kramer
Feb 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Thomas FrankTobias Moser
Mar 7, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Lisamarie LoGiudice, Gary Matthews
Nov 20, 2009·Journal of Neurophysiology·Theodore M BartolettiWallace B Thoreson
Sep 10, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tim JarskyJoshua H Singer

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