Acute dietary nitrate supplementation does not attenuate oxidative stress or the hemodynamic response during submaximal exercise in hypobaric hypoxia

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Colin R CarrikerAnn L Gibson

Abstract

The purpose of this study was to investigate changes in oxidative stress, arterial oxygen saturation (SaO2), blood pressure (BP), and heart rate (HR) during exercise in hypobaric hypoxia following acute dietary nitrate supplementation. Nine well-trained (maximal oxygen consumption, 60.8 ± 7.8 mL·kg-1·min-1) males (age, 29 ± 7 years) visited the laboratory on 3 occasions, each separated by 1 week. Visit 1 included a maximal aerobic cycling test and five 5-min increasing-intensity exercise bouts in a normobaric environment (1600 m). A single dose of either a nitrate-depleted placebo (PL) or a nitrate-rich beverage (NR; 12.8 mmol nitrate) was consumed 2.5 h prior to exercise during visits 2 and 3 (3500 m) in a double-blind, placebo-controlled, crossover study consisting of a 5-min cycling warm-up and 4 bouts, each 5 min in duration, separated by 4-min periods of passive rest. Exercise wattages were determined during visit 1 and corresponded to 25%, 40%, 50%, 60%, and 70% of normobaric maximal oxygen consumption. Catalase and 8-isoprostane were measured before and after exercise (immediately before and 1 h postexercise, respectively). NR increased plasma nitrite (1.53 ± 0.83 μmol·L-1) compared with PL (0.88 ± 0.56 μmol·L-1) (p < 0....Continue Reading

References

Jan 1, 1993·Free Radical Research Communications·R E Huie, S Padmaja
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·H SuzukiG W Schmid-Schönbein
Nov 14, 2000·Circulation Research·H Cai, D G Harrison
Jan 12, 2001·Physiological Reviews·J S Stamler, G Meissner
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P MøllerN V Olsen
Oct 5, 2001·Free Radical Biology & Medicine·A MastaloudisM G Traber
Sep 5, 2002·Free Radical Biology & Medicine·Roger Harrison
Sep 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher S Wilcox
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Jun 29, 2007·Medicine and Science in Sports and Exercise·Yiannis MichailidisDimitris Kouretas
Jul 20, 2007·Acta Physiologica·F J LarsenB Ekblom
Aug 8, 2007·The Journal of Experimental Medicine·Sruti ShivaMark T Gladwin
Jan 3, 2008·Nature Reviews. Drug Discovery·Jon O LundbergMark T Gladwin
Oct 17, 2008·Physiological Reviews·Scott K Powers, Malcolm J Jackson
May 2, 2009·Circulation Research·Victor M VictorSalvador Moncada
May 15, 2009·The American Journal of Clinical Nutrition·Norman G HordNathan S Bryan
May 15, 2010·Journal of Applied Physiology·Stephen J BaileyAndrew M Jones
Aug 13, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anni VanhataloAndrew M Jones
Nov 13, 2010·Journal of Applied Physiology·Katherine E LansleyAndrew M Jones
Dec 7, 2010·Best Practice & Research. Clinical Obstetrics & Gynaecology·Graham J Burton, Eric Jauniaux
Feb 3, 2011·Cell Metabolism·Filip J LarsenEddie Weitzberg
Apr 8, 2011·Medicine and Science in Sports and Exercise·Katherine E LansleyAndrew M Jones
Feb 23, 2012·Scientific Reports·Denny Z LevettUNKNOWN Caudwell Extreme Everest Research Group
Apr 25, 2012·European Journal of Applied Physiology·Daryl P WilkersonAndrew M Jones
May 17, 2012·Respiratory Physiology & Neurobiology·Harald K EnganErika Schagatay
Jun 13, 2012·The Journal of Physiology·Andrés HernándezHåkan Westerblad
Jul 10, 2012·Journal of Applied Physiology·Evi MasscheleinPeter Hespel
Jul 31, 2012·Free Radical Biology & Medicine·Satish Srinivasan, Narayan G Avadhani
Aug 10, 2012·Medicine and Science in Sports and Exercise·Oliver PeacockOyvind Sandbakk
Sep 26, 2012·International Journal of Sport Nutrition and Exercise Metabolism·Lindsey E MillerJohn C Quindry
Feb 12, 2013·Free Radical Biology & Medicine·Mark GilchristNigel Benjamin
Apr 13, 2013·International Journal of Sport Nutrition and Exercise Metabolism·David J MuggeridgeChris Easton
Jul 13, 2013·Medicine and Science in Sports and Exercise·David J MuggeridgeChris Easton
Dec 10, 2013·Nitric Oxide : Biology and Chemistry·Daniel B Kim-Shapiro, Mark T Gladwin
May 2, 2014·Medicine and Science in Sports and Exercise·Robert K BoorsmaLawrence L Spriet
Jul 11, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James KellyAndrew M Jones
Oct 5, 2014·Nitric Oxide : Biology and Chemistry·Scott K FergusonDavid C Poole
Nov 21, 2014·Medicine and Science in Sports and Exercise·Simone PorcelliMauro Marzorati
Apr 18, 2015·Asian Journal of Sports Medicine·Abbas YavariZahra Bahadoran
May 6, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Josh Timothy ArnoldJamie Hugo Macdonald

❮ Previous
Next ❯

Citations

Jun 1, 2019·International Journal of Food Sciences and Nutrition·Colin R CarrikerAlvaro N Gurovich
Apr 16, 2020·Critical Reviews in Food Science and Nutrition·H ZamaniS G J van Breda
May 3, 2019·Oxidative Medicine and Cellular Longevity·Eduardo F MenezesFoued S Espindola
Aug 18, 2021·Sports Health·Daniel Rojano-OrtegaFrancisco J Berral-de la Rosa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.