Acute Disseminated Intravascular Coagulation after Oxaliplatin Infusion

Chemotherapy
Mark WaddleSikander Ailawadhi

Abstract

Oxaliplatin is one of the most commonly used drugs for patients with colorectal cancer. It has rarely been associated with disseminated intravascular coagulation (DIC) with only 3 previously reported cases. In all those instances, the patients had started receiving oxaliplatin, developed evidence of DIC during the course of planned treatment, and recovered with supportive care. We report a case of a 71-year-old man with colorectal cancer treated successfully with an oxaliplatin-based regimen who had disease relapse after 3 years. When treated again with oxaliplatin, he developed signs of an acute hypersensitivity reaction, and eventually had signs and symptoms consistent with DIC despite appropriate management. This case is unique in that a DIC reaction evolving from a hypersensitivity reaction occurred after the patient had already tolerated the drug years earlier. It suggests a possible immune-mediated etiology to this rare occurrence that should be kept in mind while utilizing this commonly employed drug.

References

Oct 14, 2009·Clinical Colorectal Cancer·Edward JamesMuhammad Wasif Saif
Jul 31, 2012·World Journal of Gastrointestinal Oncology·Shweta KurianYeon Ahn
Sep 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jiaxin Niu, Martha P Mims
Feb 7, 2014·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Nicholas P ForcelloDriola Brahaj
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Johnson T WongAidan Long
Mar 29, 2014·Tumori·Sylvain GarciazJean-Luc Raoul
Aug 6, 2016·Visceral Medicine·Julian HolchVolker Heinemann

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Citations

May 24, 2020·Journal of Thrombosis and Thrombolysis·Giulia BonaldoDomenico Motola

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