Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffected

Psychopharmacology
Kim P C Kuypers, Johannes G Ramaekers

Abstract

Research concerning spatial memory in 3,4-methylenedioxymethamphetamine (MDMA) users has presented conflicting results showing either the presence or absence of spatial memory deficits. Two factors may have confounded results in abstinent users: memory task characteristics and polydrug use. The present study aims to assess whether a single dose of MDMA affects spatial memory performance during intoxication and withdrawal phase and whether spatial memory performance after MDMA is task dependent. Eighteen recreational MDMA users participated in a double-blind, placebo-controlled, three-way crossover design. They were treated with placebo, MDMA 75 mg, and methylphenidate 20 mg. Memory tests were conducted between 1.5 and 2 h (intoxication phase) and between 25.5 and 26 h (withdrawal phase) post-dosing. Two spatial memory tasks of varying complexity were used that required either storage of stimulus location alone (spatial memory task) or memory for location as well as processing of content or contextual information (change blindness task). After a single dose of MDMA, the subjects made larger localization errors and responded faster compared to placebo in the simple spatial memory task during intoxication phase. Inaccuracy was not...Continue Reading

References

Apr 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·U D McCannG A Ricaurte
Aug 27, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M J Morgan
Dec 17, 1998·Neurology·K I BollaG A Ricaurte
Jan 6, 2000·The British Journal of Psychiatry : the Journal of Mental Science·D M SempleE C Johnstone
May 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·E Gouzoulis-MayfrankH Sass
Jun 1, 2000·British Journal of Psychology·M WareingP N Murphy
Feb 24, 2001·Psychopharmacology·R J VerkesA F Cohen
Feb 19, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Liesbeth RenemanJan Booij
Aug 24, 2002·The European Journal of Neuroscience·L L MorfordC V Vorhees
Jan 2, 2003·Progress in Brain Research·Sascha M DornhoeferBoris M Velichkovsky
Apr 2, 2003·Pharmacology & Therapeutics·J C Cole, H R Sumnall
Jul 2, 2003·Physiology & Behavior·Jon E SpragueBrian Woodside
Sep 5, 2003·Psychopharmacology·Richard Ian DaftersAnnie Claire Talbot
Jan 22, 2004·Psychopharmacology·Michelle WareingJohn E Fisk
Jan 11, 2005·Human Psychopharmacology·Michelle WareingCatharine Montgomery
Nov 8, 2005·Journal of Psychopharmacology·Kim P C Kuypers, Jan G Ramaekers

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Citations

Dec 19, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Johannes G RamaekersElia Formisano
May 13, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J H P van WelJ G Ramaekers
Mar 3, 2010·Annual Review of Clinical Psychology·Emma Barkus, Robin M Murray
May 11, 2010·Neuroscience and Biobehavioral Reviews·Maria Jose Fernández-SerranoAntonio Verdejo-García
Aug 27, 2016·Journal of Psychopharmacology·E B de Sousa Fernandes PernaJ G Ramaekers
Nov 1, 2008·Journal of Psychopharmacology·K P C KuypersJ G Ramaekers
May 28, 2011·Journal of Psychopharmacology·Kim P C KuypersJohannes G Ramaekers
Aug 5, 2015·Therapeutic Advances in Psychopharmacology·David BaumeisterDerek K Tracy
May 30, 2014·Journal of Neural Transmission·Boris MlinarRenato Corradetti
Sep 6, 2012·British Journal of Pharmacology·K P C KuypersJ G Ramaekers
Apr 6, 2019·Frontiers in Psychiatry·Ben SessaDavid Nutt
Jul 28, 2018·Frontiers in Pharmacology·Elizabeth B de Sousa Fernandes PernaJohannes G Ramaekers
Sep 14, 2018·Frontiers in Behavioral Neuroscience·Bruno Lobao-SoaresAna Carolina Luchiari
Feb 27, 2020·The American Journal of Psychiatry·Collin M ReiffUNKNOWN the Work Group on Biomarkers and Novel Treatments, a Division of the American Psychiatric Association Council of Research
Oct 9, 2020·Neurobiology of Learning and Memory·Hanna SquireDavid N Harper
Oct 9, 2021·Experimental Neurology·Catharine Montgomery, Carl A Roberts

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