Acute doses of d-amphetamine and bupropion increase cigarette smoking

Psychopharmacology
M S CousinsHarriet De Wit

Abstract

Bupropion is used clinically as a treatment for smoking cessation, but the processes by which it reduces smoking are poorly understood. Bupropion shares some neurochemical actions and behavioral effects with the psychostimulant amphetamine, and it has been shown that amphetamine increases smoking when administered acutely. The effects of single doses of bupropion on smoking have not been studied but, based on its similarities to amphetamine, we postulated that acute bupropion would also increase smoking. To measure the effects of single doses of amphetamine and bupropion on smoking and craving for cigarettes in smokers. Cigarette smokers who were not trying to quit participated in a three-session study in which they received placebo and a single dose of either d-amphetamine sulfate (10 and 20 mg; n=10) or bupropion hydrochloride (150 and 300 mg; n=12) after overnight abstinence. The three outcome measures were: i) subjective and behavioral effects of amphetamine and bupropion after a period of acute abstinence, ii) effects of amphetamine and bupropion on subjective responses to a single, smoked cigarette, and iii) effects of the drugs on number of cigarettes smoked during an ad libitum smoking period. After the acute abstinence...Continue Reading

Citations

Jun 29, 2005·Psychopharmacology·Craig R RushPaul E A Glaser
Sep 16, 2005·Psychopharmacology·Kenneth A PerkinsCaryn Lerman
Apr 21, 2007·Psychopharmacology·Andrea R VansickelCraig R Rush
Jul 6, 2007·Psychopharmacology·F Joseph McClernonRachel V Kozink
May 19, 2011·Psychopharmacology·Andrea R VansickelCraig R Rush
Apr 25, 2012·Psychopharmacology·Jessica D RhodesMartin C Mahoney
Dec 4, 2013·Psychopharmacology·Kenneth A Perkins, Caryn Lerman
Feb 14, 2002·Drug and Alcohol Dependence·Michael S CousinsHarriet de Wit
Sep 22, 2005·Experimental and Clinical Psychopharmacology·Karen M AlseneHarriet de Wit
Feb 14, 2007·Experimental and Clinical Psychopharmacology·Stacey C Sigmon
Apr 13, 2011·Experimental and Clinical Psychopharmacology·Nancy K Mello, Jennifer L Newman
Aug 11, 2007·Nature Reviews. Drug Discovery·Caryn LermanWilliam A Corrigall
Jun 22, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas E WootersMichael T Bardo
Jul 23, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·E Paul WileytoCaryn Lerman
Aug 6, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·M Caterina GrassiPaolo Nencini
Jan 27, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Emma Childs, Harriet de Wit
Mar 3, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Gregory J Madden, David Kalman
Nov 10, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·William W StoopsCraig R Rush
Jun 16, 2009·Addiction Biology·Gabriela C SantosCleopatra S Planeta
Apr 2, 2003·Expert Opinion on Pharmacotherapy·Robert West
Jun 21, 2011·Expert Opinion on Investigational Drugs·Jolanda PrinsS Mechiel Korte
Aug 12, 2009·Neuroscience and Biobehavioral Reviews·Peter DomeZoltan Rihmer
Mar 14, 2009·Pharmacology, Biochemistry, and Behavior·Andrea R VansickelCraig R Rush
Jan 6, 2009·Pharmacology, Biochemistry, and Behavior·Laura E O'Dell, Taline V Khroyan
Apr 5, 2008·Clinical Pharmacology and Therapeutics·K A PerkinsK N R Chengappa
Nov 11, 2008·Annals of the New York Academy of Sciences·Jed E Rose
Feb 11, 2011·Synapse·Kirsty DanielsonBronwyn M Kivell
Jan 16, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Larry W HawkMartin C Mahoney
Jun 16, 2009·Biochemical Pharmacology·Linda P DwoskinMichael T Bardo
Jan 17, 2015·European Journal of Pharmacology·S Mechiel KorteBerend Olivier
Jul 20, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Tannetje I BronJ J Sandra Kooij

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.