Acute DWI Reductions In Patients After Single Epileptic Seizures - More Common Than Assumed

Frontiers in Neurology
Annemarie HübersElmar H Pinkhardt

Abstract

Background: Changes of cerebral diffusivity detected by magnetic resonance imaging (MRI) have been reported in epilepsy. Diffusion weighted imaging (DWI) detects changes in the distribution of water molecules by measuring the apparent diffusion coefficient (ADC) and is mainly used in the diagnosis of ischemic stroke. DWI changes in epilepsy were reported in status epilepticus (SE) or series of seizures. It remains unclear whether this phenomenon also occurs after single seizures. Accordingly, possible pathomechanisms have only been discussed on the presumed basis of ongoing epileptic brain activity. Methods: In this retrospective study, we systematically analyzed DWI alterations related to epileptic seizures in 454 patients who received MRI scanning within the first 24 h after seizure onset. Results: DWI restrictions not classified as ischemic stroke were observed in 18 patients (4%). We found DWI restrictions in 19% of patients with SE/seizure series and in 3% of patients after single focal and 2.5% after single generalized seizures. 17 patients with DWI alterations were diagnosed with a structural epilepsy. DWI signal decreased in the majority of patients within the first days and could not be detected in follow-up imaging >3...Continue Reading

References

Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J MintorovitchP R Weinstein
Mar 1, 1997·Acta Neurologica Scandinavica·O N MarkandH N Wellman
Aug 16, 1997·Lancet·U C WieshmannS D Shorvon
Apr 2, 1999·Neurology·M G LansbergG W Albers
Feb 21, 2006·Lancet Neurology·James W Y Chen, Claude G Wasterlain
Mar 17, 2007·Lancet Neurology·Hartmut Meierkord, Martin Holtkamp
Jan 15, 2009·Epilepsia·Carlo Di BonaventuraAnna T Giallonardo
Feb 13, 2009·Revue neurologique·S Dupont, A Crespel
Aug 2, 2011·Epilepsy Research·Anastasios ChatzikonstantinouKristina Szabo
Jun 18, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Thorsten BartschOlav Jansen

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Citations

Sep 22, 2018·Current Opinion in Neurology·Solène Moulin, Didier Leys
Feb 28, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Naoto KurodaTohru Okanishi
Aug 28, 2019·Nutritional Neuroscience·Olympia KremmydaAndreas Straube
Feb 11, 2020·Insights Into Imaging·Vivek PaiBela Purohit
May 7, 2020·Current Opinion in Neurology·Chu-Yueh GuoMichael D Geschwind
May 21, 2019·Current Opinion in Neurology·Roland Wiest, Roland Beisteiner
Oct 2, 2021·Neuroradiology·Siddhartha GaddamanuguAparna Singhal

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

SPSS Statistics21

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