Acute effect of a high-carbohydrate low-fat meal on platelet aggregation

Platelets
K D K AhujaM J Ball

Abstract

Conflicting information is available regarding patient preparation with respect to the fasting and feeding states prior to blood collection in order to conduct platelet aggregation tests. Some literature suggests avoidance of only high-fat foods and allowance of non-fat foods and clear liquids; others suggest a fast of 8-10 hours. We conducted a study in 16 healthy subjects aged 44.0 +/- 12.7 (mean +/- SD) years to investigate and compare the effects of fasting and a high-carbohydrate low-fat meal on measures of platelet aggregation. Blood samples collected after an overnight fast of 10-12 hours and those collected at 40 and 120 minute postprandially (post-high-carbohydrate low-fat meal; 1900 kJ energy; 69, 16 and 15% of energy from carbohydrate, protein and fat, respectively), were tested for platelet aggregation in response to adenosine diphosphate. There was a significant reduction in maximum aggregation and area under the aggregation curve from fasting to 120 minute post meal (overall p < 0.001). Serum triglyceride concentrations did not change significantly from fasting to postprandial state (p = 0.53). Although there was a significant association between serum insulin, plasma glucose and measures of platelet aggregation, ...Continue Reading

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Citations

Mar 22, 2012·European Journal of Clinical Nutrition·K D K AhujaM J Ball
Sep 5, 2012·Thrombosis Journal·Helmut Sinzinger, Robert Berent
Jun 24, 2014·Thrombosis Research·Safa Y AlmaghrabiMurray J Adams
Jan 2, 2013·Pathology·Natasha A BettsMurray J Adams
Jul 8, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Anita A PalatinusMurray J Adams
Apr 11, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Safa AlmaghrabiKiran Ahuja
Nov 11, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Yik C HoMurray J Adams
Mar 8, 2018·International Journal of Laboratory Hematology·L PolgárL Kőhidai

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