Acute effect of bisphenol A: Signaling pathways on calcium influx in immature rat testes

Reproductive Toxicology
Renata GonçalvesFátima Regina Mena Barreto Silva

Abstract

We investigated the acute effect of low concentrations of BPA on calcium influx and the mechanism of action of BPA in this rapid response in the rat testis. BPA increased calcium influx at 1 pM and 1 nM at 300 s of incubation, in a similar manner to that of estradiol. At 1 pM, BPA stimulated calcium influx independently of classical estrogen receptors, consistent with a G-protein coupled receptor. This effect also involves the modulation of ionic channels, such as K+, TRPV1 and Cl- channels. Furthermore, BPA is able to modulate calcium from intracellular storages by inhibiting SERCA and activating IP3 receptor/Ca2+ channels at the endoplasmic reticulum and activate kinase proteins, such as PKA and PKC. The rapid responses of BPA on calcium influx could, in turn, trigger a cross talk by MEK and p38MAPK activation and also mediate genomic responses.

Citations

May 5, 2020·Journal of Biochemical and Molecular Toxicology·Catya Jiménez-TorresArturo Ortega
Aug 2, 2018·International Journal of Molecular Sciences·Paulina Urriola-MuñozRicardo D Moreno
Feb 8, 2020·Journal of Clinical Medicine·Sophie-Christine de Aguiar GrecaEmmanouil Karteris
Dec 9, 2020·Nature Reviews. Endocrinology·David Lopez-RodriguezAnne-Simone Parent
Jun 22, 2020·Ecotoxicology and Environmental Safety·Hemily Batista-SilvaFátima Regina Mena Barreto Silva
Aug 13, 2020·Chemosphere·Keyla RodriguesFátima Regina Mena Barreto Silva
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Olufunke E Ola-Davies, Samuel G Olukole

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