Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies

Neuropharmacology
Katarzyna SocałaPiotr Wlaź

Abstract

Cannabidiol and cannabidiol-enriched products have recently attracted much attention as an add-on therapy for epilepsy, especially drug-resistant seizures. It should be, however, remembered that concomitant use of cannabidiol and antiepileptic drugs may pose a risk of interactions between them. For this reason, the aim of our study was to assess the effect of cannabidiol on the activity of selected new antiepileptic drugs in the electrically-induced seizure models in mice. We studied the effect of cannabidiol on the anticonvulsant action of topiramate, oxcarbazepine, lamotrigine, and pregabalin in the maximal electroshock-induced seizure test as well as on the activity of levetiracetam, tiagabine, lacosamide, and gabapentin in the 6 Hz seizure test in mice. We showed that cannabidiol increased the activity of topiramate, oxcarbazepine, pregabalin, tiagabine, and gabapentin. It did not affect the anticonvulsant effect of lamotrigine and lacosamide. Interestingly, cannabidiol attenuated the anticonvulsant activity of levetiracetam. Co-administration of antiepileptic drugs with cannabidiol did not cause adverse effects such as impairment of motor coordination, changes in neuromuscular strength or potentiation of the cannabidiol-in...Continue Reading

Citations

Mar 17, 2020·Expert Opinion on Drug Metabolism & Toxicology·Claudiu T Supuran
Sep 21, 2020·Neuroscience·Charalampos BrakatselosKaterina Antoniou
Feb 6, 2021·Seizure : the Journal of the British Epilepsy Association·Christopher G S GilmartinPooja Harijan
Jan 31, 2021·Journal of General Internal Medicine·Premalatha BalachandranKevin P Hill
Apr 22, 2021·Seizure : the Journal of the British Epilepsy Association·Christian Lizette Frías-SoriaLuisa Rocha
May 1, 2021·International Journal of Environmental Research and Public Health·Aaron M FarrellyKonstantinos Grintzalis
Jul 31, 2021·Toxicology and Applied Pharmacology·Mateusz PierógPiotr Wlaź
Jul 9, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kwabena F M OpuniCharles A Okai

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