Acute effect of corticosterone on N-methyl-D-aspartate receptor-mediated Ca2+ elevation in mouse hippocampal slices

Biochemical and Biophysical Research Communications
Satoru SatoSuguru Kawato

Abstract

We examined the rapid effects of corticosterone (CORT) on N-methyl-D-aspartate (NMDA) receptor-mediated Ca2+ signals in adult mouse hippocampal slices by using Ca2+ imaging technique. Application of NMDA caused a transient elevation of intracellular Ca2+ concentration followed by a decay to a plateau within 150s. The 30min preincubation of CORT induced a significant decrease of the peak amplitude of NMDA-induced Ca2+ elevation in the CA1 region. The rapid effect of CORT was induced at a stress-induced level (0.4-10microM). Because the membrane non-permeable bovine serum albumin-conjugated CORT also induced a similar rapid effect, the rapid effect of CORT might be induced via putative surface CORT receptors. In contrast, CORT induced no significant effects on NMDA-induced Ca2+ elevation in the dentate gyrus. In the CA3 region, CORT effects were not evaluated, because the marked elevation of NMDA-induced Ca2+ signals was not observed there.

References

Sep 24, 1986·Brain Research·C VidalW Zieglgänsberger
Jun 1, 1997·Brain Research. Brain Research Reviews·S J Lupien, B S McEwen

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Citations

Oct 19, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yi-Ling YangKwok-Tung Lu
Feb 26, 2010·Molecular Brain·Therese RiedemannOsborne F X Almeida
Jun 11, 2008·Molecular and Cellular Endocrinology·Yasushi HojoSuguru Kawato
Apr 27, 2013·Acta Psychiatrica Scandinavica·J D Gray, B S McEwen
Aug 23, 2005·Biochemical and Biophysical Research Communications·Yoshimasa KomatsuzakiSuguru Kawato
Mar 29, 2014·Biochimica Et Biophysica Acta·Elisa Martin-MontañezMaria Garcia-Fernandez
Nov 12, 2013·Progress in Neurobiology·M R Bennett, J Lagopoulos
Dec 14, 2011·Cell Calcium·Marian Joëls, Henk Karst
Jan 27, 2010·Pharmacology, Biochemistry, and Behavior·Teresa A BarberBrian F McGettigan
Nov 19, 2008·The Australian and New Zealand Journal of Psychiatry·Maxwell R Bennett A O
Jul 3, 2013·The Journal of Biological Chemistry·Silei YangOsborne F X Almeida

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